J Korean Soc Transplant.  2010 Sep;24(3):182-186. 10.4285/jkstn.2010.24.3.182.

Crude Incidence Rate of Malignancy after Kidney Transplantation

• Kim HS
• Seo YM
• Park UJ
• Kim HT
• Cho WH
• Hwang EA
• Han SY
• Park SB
• Kim HC
• Jang HS
• Joo SH

• KMID: 1464311
• DOI: http://doi.org/10.4285/jkstn.2010.24.3.182

Abstract

BACKGROUND
The incidence pattern of malignancy after kidney transplantation is different from that of the general population. Because increased exposure to immunosuppressants results in an increased incidence of malignancy, institutional reports that do not consider duration of immunosuppression have limited value for providing future kidney recipients with the actual risk for malignancy or for developing a kidney allograft recipient surveillance program. Thus, we retrospectively analyzed our institutional data with regard to the duration of exposure to immunosuppressants.
METHODS
A total of 757 patients who had kidney transplantation and were followed-up for at least 6 months at our hospital were reviewed retrospectively. The crude incidence rate (CI) was calculated by counting the days of exposure to immunosuppressants.
RESULTS
Most malignancies after kidney transplantation were solid tumors (85.3%). The CI of malignancies was 641.1 in allograft recipients and 329.6 in the general population per 100,000 persons per year. Solid tumor cancers of the stomach, liver, lung, breast, cervix, and pancreas showed an increased CI in the allograft recipient group than the general population but cancers of the thyroid and colon did not. Based on the type of immunosuppressive agent, the CI was highest in the cyclosporine group (866/12 months/100,000 persons) than the other groups.
CONCLUSIONS
We have provided the CIs of cancers after kidney transplantation at our institute. The pattern of post-transplant malignancy is different from that of western countries. Nationwide registration is needed to provide a more rational approach to post-transplant cancer surveillance in Korea.

Keyword

Post-transplant malignancy; Crude incidence rate; Postoperative complications

MeSH Terms

Breast
Cervix Uteri
Colon
Cyclosporine
Female
Humans
Immunosuppression
Immunosuppressive Agents
Incidence
Kidney
Kidney Transplantation
Korea
Liver
Lung
Pancreas
Postoperative Complications
Retrospective Studies
Stomach
Thyroid Gland
Transplantation, Homologous
Cyclosporine
Immunosuppressive Agents

Figure

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  Fig. 1. Crude incidence rate of overall malignancy (number/12 months/100,000 population).

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  Fig. 2. Crude incidence rate according to immunosuppressive agents (number/12 months/100,000 population).

Reference

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