J Korean Geriatr Psychiatry.  2010 Jun;14(1):20-26.

An Association Study between Various Adrenergic Alpha 2 Receptor Polymorphisms and Treatment Response to Mirtazapine in Major Depression

Affiliations
  • 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dohkwan.kim@samsung.com
  • 2Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea.
  • 3Department of Psychiatry, Keyo Hospital, Uiwang, Korea.
  • 4Department of Psychiatry, Bundang Jesaeng Hospital, Sungnam, Korea.

Abstract


OBJECTIVES
Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among patients suffering from major depression. This study investigated a possible association of treatment response to mirtazapine with various adrenergic alpha 2 receptor polymorphisms in major depressive patients.
METHODS
A 6-week naturalistic treatment study with a blinded outcome examined 84 Korean patients with major depression. Treatment response to mirtazapine was defined as > or =50% decrease in HAM-D scores at six weeks. In this study, four genetic polymorphisms were selected ; ADRA2A MspI, ADRA2A DraI, alpha2BDel301-303, and alpha2CDel322-325.
RESULTS
The Del/Del genotype of alpha2CDel322-325 exhibited a significant association with response to mirtazapine through multiple logistic regression. ADRA2A DraI, alpha2BDel301-303, and alpha2CDel322-325 did not showed a significant association with response to mirtazapine.
CONCLUSION
Based on the finding that alpha2CDel322-325 polymorphism had an association with the mirtazapine response, we postulate that the polymorphism related to the mechanism of the antidepressant effect is important in predicting the response to antidepressants.

Keyword

Mirtazapine; Single nucleotide polymorphism; Pharmacogenetics; Major depression; Adrenergic receptor
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