Intest Res.  2011 Apr;9(1):35-39. 10.5217/ir.2011.9.1.35.

Two Cases of Crohn's Disease Presented with Hematochezia in Patients with Hemophilia

Affiliations
  • 1Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea. hjkim@khmc.or.kr

Abstract

The etiology of Crohn's disease, which is a chronic inflammatory condition that potentially involves any location of the alimentary tract from the mouth to the anus, is unknown. However, there is strong evidence that vascular damage could play a role in the pathogenesis of Crohn's disease. Crohn's disease is mediated by multifocal gastrointestinal infarctions, which occur at an early stage in the disease process. Persistent activation of coagulation in patients with Crohn's disease has been shown. In contrast, hemophilia is an inherited disorder of coagulation. The deficiencies of clotting factors usually involve occult or overt bleeding. The pathogenic mechanisms of Crohn's disease and hemophilia are incompatible. An association between Crohn's disease and hemophilia has not been reported in Korea. We managed 21- and 33-year-old men with Crohn's disease associated with hemophilia, who presented with hematochezia.

Keyword

Crohn's Disease; Hemophilia; Inflammatory Bowel Diseases

MeSH Terms

Adult
Anal Canal
Crohn Disease
Gastrointestinal Hemorrhage
Hemophilia A
Hemorrhage
Humans
Infarction
Inflammatory Bowel Diseases
Korea
Male
Mouth
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