Korean J Dermatol.  2011 May;49(5):468-472.

Diffuse Large B-cell Lymphoma in a Patient with Angioimmunoblastic T-cell Lymphoma

• Lee HM
• Moon HR
• Kim JE
• Won CH
• Chang SE
• Lee MW
• Choi JH
• Moon KC
• Lee HJ

Abstract

Sequential lymphoma is defined as two different types of lymphoma that occur in the same patient at different anatomic sites and times. In most cases, the two distinct histologies belong to the same lineage (B- or T-cell lymphoma), though cases with both have been observed. A few cases of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas arising in patients with angioimmunoblastic T cell lymphoma (AITL) have been reported. Immune deficits inherent in AITL, combined with the immunosuppressive effects of the therapy, may have allowed unchecked EBV-induced proliferation of latently or newly EBV-infected B cells with eventual clonal selection and progression to aggressive B-cell lymphoma. Here, we report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) arose 9 months after the initial diagnosis of AITL.

Keyword

Angioimmunoblastic T cell lymphoma; Diffuse large B cell lymphoma; Sequential lymphoma

MeSH Terms

B-Lymphocytes
Herpesvirus 4, Human
Humans
Lymphoma
Lymphoma, B-Cell
Lymphoma, T-Cell
T-Lymphocytes