Korean J Pediatr Gastroenterol Nutr.  2011 Dec;14(Suppl 1):S42-S46. 10.5223/kjpgn.2011.14.Suppl1.S42.

Stem Cell in Pediatric Gastrointestinal Tract Disease: Hirschsprung Disease

• Bae SH

• KMID: 1451148
• DOI: http://doi.org/10.5223/kjpgn.2011.14.Suppl1.S42

Abstract

Stem cell is characterized with self-renewal and mult-potency. Many pediatric gastrointestinal diseases have defect in enterocytes, enteric nervous system, and Interstitial cell of Cajal. Various kinds of stem cell could be applied to these diseases. Here, the author introduces stem cell for pediatric gastrointestinal diseases, particularly Hirschsprung disease.

Keyword

Stem cell; Hirschsprung disease

MeSH Terms

Enteric Nervous System
Enterocytes
Gastrointestinal Diseases
Gastrointestinal Tract
Hirschsprung Disease
Stem Cells

Figure

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  Fig. 1 Lineage tracing in the small intestine confirms intestinal stem cells. In this case, LacZ activity was used as a reporter gene8).

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  Fig. 2 Neurons from transplanted neurospheres regulate the contractility of developing gut. EMNS and NHNS transplanted bowel have comparable contraction frequencies to ganglionic distal colon, but have significantly lower contraction frequencies than aganglionic distal colon, demonstrating a functional effect of neurosphere transplantation18). EMNS: aganglionic distal colon transplanted with embryonic mouse neurosphere, NHNS: aganglionic distal colon transplanted with neonatal human neurosphere, TTX: tetrodotoxin.

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