Anat Cell Biol.
2011 Sep;44(3):169-175. 10.5115/acb.2011.44.3.169.
Proapoptotic role of nuclear clusterin in brain
- Affiliations
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- 1Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea. choiws@gnu.ac.kr
- KMID: 1447428
- DOI: http://doi.org/10.5115/acb.2011.44.3.169
Abstract
- Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
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