Lab Anim Res.  2011 Dec;27(4):317-325. 10.5625/lar.2011.27.4.317.

Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by beta-adrenoceptor

Affiliations
  • 1College of Veterinary Medicine, Kyungpook National University, Daegu, Korea. twkim@mail.knu.ac.kr
  • 2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea.
  • 3Reclaimed Land Agriculture Research Division, National Institute of Crop Science, RDA, Iksan, Korea.
  • 4Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 5Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 6Department of Physiology and Neuroscience, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.

Abstract

Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water fraction of the extract (SAWF) on antral motility in vitro. Muscle strips from rat gastric antrum were set up in an organ bath in a circular orientation. SAWF (100 microg/mL) inhibited the spontaneous contraction of antral circular muscle strips. These inhibitory effects were not significantly affected by tetrodotoxin (1 microM), N omega-Nitro-L-arginine methyl ester hydrochloride (100 microM), 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (10 microM), ryanodine (10 microM) and phentolamine (10 microM). SAWF-induced inhibition was mostly restored by cyclopiazonic acid (10 microM). Furthermore, the beta-adrenergic receptor antagonist, propranolol (10 microM), abolished SAWF-induced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via a-adrenergic receptors and sarcoplasmic reticulum Ca2+ ATPase.

Keyword

Suaeda asparagoides; gastric antrum; spontaneous contraction; beta-adrenoceptor; SERCA
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