Lab Anim Res.  2011 Dec;27(4):309-316. 10.5625/lar.2011.27.4.309.

Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications

Affiliations
  • 1Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
  • 2Department of Diagnostic Radiology, College of Medicine, Chosun University Hospital, Gwangju, Korea.
  • 3College of Veterinary Medicine, Biotherapy Human Resources Center, Chonnam National University, Gwangju, Korea.
  • 4Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea. hjhan@snu.ac.kr

Abstract

Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in the MRI instrument, landmarks were previously traced on the snout of the pig. To avoid movements, animal were anesthetized. The animals were placed in a prone position in a Siemens Magnetom Avanto 1.5 System with a head coil. Axial T2-weighted and sagittal T1-weighted MRI images were obtained from each pig. Afterwards, the brains of the pigs were fixed and cut into axial sections. Histologic and MR images were compared. The usefulness of this technique is discussed.

Keyword

Brain; Yukatan minipigs; magnetic resonance imaging; neurologic disorder
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