Lab Anim Res.  2011 Dec;27(4):275-281. 10.5625/lar.2011.27.4.275.

Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles

Affiliations
  • 1Huvet Co., Ltd, Iksan, Korea.
  • 2Center for Animal Resources Development, Wonkwang University, Iksan, Korea. soowan@jbnu.ac.kr
  • 3Clinical Trial Center for Functional Foods, and Chonbuk National University Hospital, Jeonju, Korea.
  • 4Clinical Trial Center, Chonbuk National University Hospital, Jeonju, Korea.
  • 5Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Korea.

Abstract

Constipation is one of the most common functional digestive complaints worldwide. We investigated the laxative effects of figs (Ficus carica L) in a beagle model of constipation induced by high protein diet and movement restriction. The experiments were consecutively conducted over 9 weeks divided into 3 periods of 3 weeks each. All 15 beagles were subjected to a non-treatment (control) period, a constipation induction period, and a fig paste treatment period. We administered fig paste (12 g/kg daily, by gavage) for 3 weeks following a 3-week period of constipation induction in dogs. Segmental colonic transit time (CTT) was measured by counting radiopaque markers (Kolomark) using a radiograph performed every 6 h after feeding Kolomark capsules, until capsules were no longer observed. Fig paste significantly increased fecal quantity in constipated dogs, and segmental CTT was also reduced following fig paste administration. There were no significant differences in feed intake, water intake, body weight, or blood test results, between the constipation and fig paste administration periods. Our results demonstrate that fig is an effective treatment for constipation in beagles. Specifically, stool weight increased and segmental CTT decreased. Fig pastes may be useful as a complementary medicine in humans suffering from chronic constipation.

Keyword

Constipation; fig paste; segmental colonic transit time; Kolomark; beagle dog

MeSH Terms

Animals
Body Weight
Capsules
Carica
Colon
Complementary Therapies
Constipation
Diet
Dogs
Drinking
Ficus
Hematologic Tests
Humans
Ointments
Stress, Psychological
Capsules
Ointments

Figure

  • Figure 1 Effects of fig paste on change in body weight in each beagle experimental period (n=15).

  • Figure 2 Effects of fig paste on fecal weight in each experimental period (n=15). Bars with different letters from the control are significantly different (P<0.05).

  • Figure 3 Effects of fig paste on radiographic measurement of Kolomark transit in each experimental period (n=15). Rt.: right, Lt.: left, Rs.: rectosigmoid.

  • Figure 4 Effects of fig paste on change in segmental CTT for each experimental period (n=15). Bars with different letters from the control are significantly different (P<0.05). Rt.: right, Lt.: left, Rs.: rectosigmoid.


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