J Korean Bone Joint Tumor Soc.  2011 Dec;17(2):65-72. 10.5292/jkbjts.2011.17.2.65.

How to Overcome Complications of Allograft Transplantation?

• Cho Y
• Choi Y
• Kwon YH
• Chung SH
• Kim JD

• KMID: 1444791
• DOI: http://doi.org/10.5292/jkbjts.2011.17.2.65

Abstract

PURPOSE
We evaluated the complications of allograft reconstruction after a bone tumor resection, and reviewed literatures to overcome such complications.
MATERIALS AND METHODS
We retrospectively reviewed clinical records and radiographs of fifteen patients in whom reconstruction with allograft after bone tumor resection.
RESULTS
Eight patients were men and seven were women with a mean age of 27.1 years (1-56 years) and a mean follow-up period of 89.5 months (33-165 months). All postoperative complications related to the allograft were recorded. Twenty patients (80.0%) obtained a radiologic bony union at a mean of 8.35 months (4-12 months). The mean Musculoskeletal Tumor Society score was 73.5% (46.6-93.0%). Nine patients (60.0%) experienced one event and 3 (20.0%) patients experienced multiple events during the follow-up period. Recorded events were infection (3), fracture (2), nonunion (2), limb length discrepancy (2) and varus deformity (2). The mean event free survival period was 60.8 months (6-144 months). The mean allograft survival period was 80.2 months and the 5 year survival rate of the allografts was 83.0%.
CONCLUSION
In order to overcome complications, the combination of an allograft and vascularized fibular graft is highly recommended. In the near future, the tissue engineering technique, the application of the stem cell and PRP, could reduce the complication of allograft such as resorption and nonunion.

Keyword

bone tumor; allograft transplantation; complication

MeSH Terms

Congenital Abnormalities
Disease-Free Survival
Extremities
Female
Follow-Up Studies
Humans
Male
Postoperative Complications
Retrospective Studies
Stem Cells
Survival Rate
Tissue Engineering
Transplantation, Homologous
Transplants

Figure

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  Figure 1. This graph shows the allograft-related complications that occurred in patients (NU, nonunion; LLD, limb length discrepancy).

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  Figure 2. The Kaplan-Meier survival curve represents event free survival for all patients.

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  Figure 3. The Kaplan-Meier survival curve represents allograft survival for all patients.

Reference

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