Korean J Gastrointest Endosc.  2011 Jul;43(1):47-51.

A Case of Churg-Strauss Syndrome Manifesting as Colonic Aphthous Ulcers with Granuloma

Affiliations
  • 1Department of Internal Medicine Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. n-hkim@paik.ac.kr
  • 2Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Abstract

Churg-Strauss syndrome is characterized by asthma, peripheral and tissue eosinophilia, extravascular granuloma formation, and vasculitis of multiple organ systems. The gastrointestinal tract may be involved in 20% to 50% of patients, mainly with abdominal pain, diarrhea and GI bleeding. Ulcers in the small and large bowel are an uncommon manifestation, usually detected during laparotomy performed in the setting of bowel perforation. Endoscopically proven segmental colonic aphthous ulcers with typical pathologic findings such as extravascular granuloma formation, eosinophilic infiltration, or vasculitis are a rarer manifestation. We present a patient with Churg-Strauss syndrome and two aphthous ulcers in the sigmoid colon that healed after treatment with high dose steroids and cyclophosphamide.

Keyword

Churg-Strauss syndrome; Colon; Aphthous ulcer; Granuloma

MeSH Terms

Abdominal Pain
Asthma
Churg-Strauss Syndrome
Colon
Colon, Sigmoid
Cyclophosphamide
Diarrhea
Eosinophilia
Eosinophils
Gastrointestinal Tract
Granuloma
Hemorrhage
Humans
Laparotomy
Steroids
Stomatitis, Aphthous
Ulcer
Vasculitis
Cyclophosphamide
Steroids
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