Cardiac Toxicities Associated with Herbal Remedies

Jung, Woo Jin; Kim, Hyun; Cha, Yong Sung; Kim, Oh Hyun; Cha, Kyoung Chul; Lee, Kang Hyun; Hwang, Sung Oh

Abstract

PURPOSE
Herbal preparations have long been used for medical purposes by traditional cultures, and their use is increasing in modern societies. However, many herbal agents produce specific cardiovascular toxicities in humans. We performed this study in order to investigate the clinical characteristics of the cardiac toxicities associated with herbal remedies.
METHODS
We conducted a retrospective study of 45 patients (mean age 57+/-10 years) who presented with cardiotoxicity between January 2007 and May 2011 due to ingestion of herbal remedy substances. Patients were identified as suffering cardiotoxicity if they presented with chest pain, EKG abnormality, and elevation of cardiac enzyme.
RESULTS
Of the 45 total cases, 17 included hemodynamic instability (37.8%), 7 with increasing cardiac enzyme (15.6%), 2 with cardiac arrest (4.4%) and one case of mortality (2.2%). The cardiotoxic herb group that demonstrated the worst clinical course was Ranunculaceae.
CONCLUSIONS
In our study results, 57.6% of the herbal intoxication patients demonstrated the effects of cardiotoxicity. Thus, we recommend careful monitoring of herbal intoxication patients.