Evaluation of Effect of Silvernanoparticle Treated Implant on Bone Formation

Kim, Sin Guen; Yoon, Youn Jin; Lee, Young Man; Lee, Tae Sun; Choi, Dong Won; Song, Yun Jung; Park, Jun Woo; Choi, Dong Ju

Abstract

PURPOSE
To evaluate the effect of silvernanopartilce treated implants on the bone formation and osseointegration.
METHODS
Silvernanoparticle was produced using an anodic oxidation method. The size of silvernanoparticle ranged from 3.5 nm to 5.9 nm. To check the effect of the capability of osseointegration of silvernanoparticle coated Implant, 32 implants (16 piece of Implant treated with nanoparticle, and 16 piece of Implant was not treated for control) were placed at both the tibia of 8 New Zealand white rabbits. After 4 weeks, 4 rabbits were sacrificed and the removal torque was measured for comparison of the osseointagration ability. Further, 4 rabbits were sacrificed and sliced samples were made. H&E stain was done for microscopic finding.
RESULTS
The removal torque of the experimental group was 102.37+/-30.54 N/cm, and the control group was 73.30+/-19.97 N/cm. It was statistically significant (P<0.001). Microscopic finding also shows extinguish results in silvernanoparticle treated implants. Bone formation rate of the experimental group was 43.94% and the control group was 7.58%. It was observed to be statistically significant (P=0.017). Bone to implant contact rate of the experimental group was 58.09%, and the control group was 19.43%. It was found with statistical significance (P<0.001).
CONCLUSION
The silvernanopartilce treated implant shows a better capability of bone regeneration and osseointegration than the non-treated one. Technology to produce smaller particles would make silver more useful and safer.