Nucl Med Mol Imaging.  2013 Jun;47(2):73-80.

Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson's Disease

Affiliations
  • 1Department of Nuclear Medicine, Korea University Medical Center, Seoul, Korea. larrycheon@gmail.com
  • 2Department of Neurology, Korea University Medical Center, Seoul, Korea.
  • 3Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease.
METHODS
Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic AnatomicalMap (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method.
RESULTS
All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manualmethods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region.
CONCLUSIONS
Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.

Keyword

Parkinson's disease; F-18 FP-CIT PET; Template-based quantitative analysis; Korean statistical probabilistic anatomical map (KSPAM); Dopamine transporter (DAT)

MeSH Terms

Cerebellum
Humans
Hypogonadism
Mitochondrial Diseases
Ophthalmoplegia
Parkinson Disease
Putamen
Tropanes
Hypogonadism
Mitochondrial Diseases
Ophthalmoplegia
Tropanes
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