Korean J Perinatol.  2013 Mar;24(1):20-28. 10.14734/kjp.2013.24.1.20.

Blood Urea Nitrogen Concentration and Aggressive Parenteral Amino Acid Administration in Extremely Low Birth Weight Infants during the First Week

  • 1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. neopark@hanyang.ac.kr


Early administration of parenteral amino acids has been shown to limit catabolism and improve growth in extremely low birth weight infants (ELBWI). This study aimed to evaluate the relationship between an earlier aggressive administration of amino acids and blood urea nitrogen (BUN).
We retrospectively analyzed the medical records of all ELBWI who were born and admitted to Hanyang University Hospital from March 2007 to December 2009. The high initial dose group received > or =3.0 g/kg/d amino acids, while the lower initial dose group did not received a minimum of > or =3.0 g/kg/d parenteral AA at < or =3 days of age.
There were no differences in gestational age, birth weight and sex between the groups. Mean fluid intake and total calories during the first 48 hours of life were similar between two groups. There is no correlation between amino acid intake and BUN level in ELBWI during study period. However, gestational age showed a significant negative correlation with BUN level in ELBWI on day 3 and 7.
An earlier, more aggressive administration of amino acids was safe and well-tolerated. There is no correlation between amino acid intake and BUN level in ELBWI infants within 7 days of life.


Blood urea nitrogen; Amino acid; Nutrition; Extremely low birth weight infants
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