Korean J Blood Transfus.  2012 Dec;23(3):267-271.

A First Experience of Rh(D) Incompatible Living Related Liver Transplantation in Korea

Affiliations
  • 1Department of laboratory Medicine, Pusan National University School of Medicine, Busan, Korea. hhkim@pusan.ac.kr
  • 2Department of Surgery, Pusan National University School of Medicine, Busan, Korea.
  • 3Medical Research Institute, Pusan National University Hospital, Busan, Korea.

Abstract

To expand the indications for living liver allograft, an increasing number of clinical trials of ABO incompatible liver transplantation have been reported in the literature. Administration of immunosuppressive drugs has resulted in decreased rates of mortality and graft loss in patients undergoing in ABO-incompatible living donor liver transplantation (LDLT). Rh incompatibility in liver transplantation has not been reported as frequently as that of ABO-incompatible LDLT. Rh-antigens are said to be located only on red blood cells, and have not been demonstrated on leukocytes or tissue cells. For this reason, the incompatibility of Rh antigen between the donor and the recipient has received significantly less consideration in organ transplantations. Here, we report on a case of Rh incompatible living related liver transplantation from a group O, Rh-positive donor to a group O, Rh-negative recipient. The recipient did not develop Rh alloimmunization after administration of immunosupressive drugs and Rh immunoglobin (RhIG).

Keyword

RH incompatible; Liver transplantation; Living donor; Alloimmunization; Anti-D
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