J Korean Med Sci.  1986 Sep;1(1):37-41. 10.3346/jkms.1986.1.1.37.

Therapy of severe aplastic anemia with anti-human thymocyte globulin (ATGAM) with and without HLA-haploidentical bone-marrow infusion

Affiliations
  • 1Department of Pediatrics, Yonsei University, College of Medicine Seoul, Korea.

Abstract

Six patients with severe aplastic anemia treated with horse anti-human thymocyte globulin (ATG) and androgen. Four of these patients were only given ATG (ATGAMR), 16 mg/Kg/dose x 10 doses. The remaining two cases received an infusion of maternal HLA-haploidentical marrow cells following ATG therapy. One patient had a complete response, three had a partial response, one showed minimal improvement and two were non-responders. The two patients who received the additional haploidentical marrow cells showed a hematologic recovery sooner than the ATG alone cases. The toxicity of the ATG therapy was tolerable. Long term follow up of there patients and further studies of this treatment in aplastic anemia with pediatric age group are under way.

Keyword

Severe aplastic anemia; Anti-human thymocyte globulin (ATG, ATGAM); HLA-haploidentical bone-marrow infusion

MeSH Terms

Anemia, Aplastic/*therapy
Antilymphocyte Serum/adverse effects/*therapeutic use
*Bone Marrow Transplantation
Child
Child, Preschool
Female
HLA Antigens/genetics
Haplotypes
Humans
Male
Antilymphocyte Serum
HLA Antigens
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