Yonsei Med J.  2006 Oct;47(5):741-744. 10.3349/ymj.2006.47.5.741.

Acute Lymphoblastic Leukemia Associated with Brucellosis in Two Patients with Fever and Pancytopenia

  • 1Department of Hematology-Oncology, Erciyes University School of Medicine, Kayseri, Turkey. beser@erciyes.edu.tr
  • 2Department of Pathology, Erciyes University School of Medicine, Kayseri, Turkey.


Brucellosis is a disease involving the lymphoproliferative system, which may lead to changes in the hematological parameters; however, pancytopenia is a rare finding. However, malignant diseases in association with brucellosis are rarely the cause of pancytopenia. Herein, two cases with fever and pancytopenia, diagnosed as simultaneous acute lymphoblastic leukemia and brucellosis are presented. Anti-leukemic therapy and brucellosis treatment were administered simultaneously, and normal blood parameters obtained. The first patient is in complete remission; the other recovered from the brucellosis, but later died due to a leukemic relapse.


Acute lymphoblastic leukemia; brucellosis; pancytopenia
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