J Korean Rheum Assoc.  2008 Mar;15(1):1-10. 10.4078/jkra.2008.15.1.1.

Intracellular Signal Transduction Pathways and Transcription Factors for Osteogenesis

• Im GI

• KMID: 1324504
• DOI: http://doi.org/10.4078/jkra.2008.15.1.1

Abstract

Osteoblastic differentiations of mesenchymal stem cells are controlled by a number of intracellular signal transduction systems and transcription factors. These systems and factors interacts with and cross-talks to one another to complete the process of bone formation. Discovery of these systems has been enabled by gene-targeting techniques. In this brief review, the signal transduction pathways and transcription factors of importance to osteoblastic differentiation are introduced.

Keyword

Signal transduction pathway; Transcription factor; Osteogenesis; Bone