Korean J Pathol.  2012 Jun;46(3):261-265. 10.4132/KoreanJPathol.2012.46.3.261.

The Expression of Pigment Epithelium-Derived Factor in Bladder Transitional Cell Carcinoma

  • 1Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea. taejung@mail.dongguk.ac.kr
  • 2Department of Radiology, Dongguk University College of Medicine, Gyeongju, Korea.
  • 3Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea.


Pigment epithelium-derived factor (PEDF) is an anti-angiogenic factor. The purpose of this study is to examine the involvement of PEDF in the angiogenesis and biological behavior of bladder transitional cell carcinoma (TCC).
We examined the expression of PEDF in 99 bladder TCCs and ten non-neoplastic tissues, and evaluated microvessel density (MVD).
The positive immunoreactivity for PEDF was seen in normal urothelium in 60% (6/10) and TCC in 13% (13/99). The PEDF expression had a significant correlation with MVD, i.e., a low MVD in 42% (5/12), a middle MVD in 11% (8/76) and a high MVD 0% (0/11) of tumors. The PEDF expression was not significantly correlated with the differentiation and invasion of TCC, but the degree of MVD was significantly higher in both high grade TCC and the pT2 tumors.
The degree of PEDF expression is significantly higher in normal bladder urothelium than bladder TCC; it is inversely correlated with the angiogenesis; and it is not related to the differentiation and progression of TCC. It can therefore be concluded that bladder TCC would initially occur if there is a lack of the PEDF expression.


Bladder transitional cell carcinomas; Angiogenesis; Pigment epithelium-derived factor
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