Korean J Ophthalmol.  2012 Feb;26(1):61-64. 10.3341/kjo.2012.26.1.61.

Resolution of Recalcitrant Uveitic Optic Disc Edema Following Administration of Methotrexate: Two Case Reports

• Woo SJ
• Kim MJ
• Park KH
• Lee YJ
• Hwang JM

• KMID: 1120185
• DOI: http://doi.org/10.3341/kjo.2012.26.1.61

Abstract

A 13-year-old male and a 15-year-old female presented with optic disc edema associated with chronic recurrent uveitis. While the ocular inflammation responded to high doses of oral prednisolone, the disc edema showed little improvement. After oral administration of methotrexate, the disc edema and ocular inflammation were resolved, and the dose of oral corticosteroid could be reduced.

Keyword

Child; Disc edema; Methotrexate; Ocular inflammation; Uveitis

MeSH Terms

Administration, Oral
Adolescent
Chronic Disease
Female
Glucocorticoids/administration & dosage
Humans
Immunosuppressive Agents/administration & dosage
Male
Methotrexate/administration & dosage
Papilledema/drug therapy/*etiology
Prednisolone/administration & dosage
Recurrence
Uveitis/*complications/drug therapy

Figure

• 

  Fig. 1 Case 1. Fundus photographs of case 1. (A,B) At presentation, bilateral severe disc edema and vascular tortuosity were observed. (C,D) Three weeks after administration of methotrexate, disc edema and vascular tortuosity were resolved.

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  Fig. 2 Case 2. A fundus photograph (A) and fluorescein angiography (B) of the right eye revealing disc edema and choroiditis. (C,D). One month after administration of methotrexate, the disc edema and fluorescein leakage from the optic disc were resolved.

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