Korean J Ophthalmol.  2011 Apr;25(2):73-76. 10.3341/kjo.2011.25.2.73.

Investigating the Relationship between Serum Interleukin-17 Levels and Systemic Immune-Mediated Disease in Patients with Dry Eye Syndrome

Affiliations
  • 1Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea. kmk9@snu.ac.kr
  • 2Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases.
METHODS
IL-17 and IL-23 levels were measured in the sera of patients whose tear production was <5 mm on the Schirmer test. Subjects included patients with chronic graft-versus-host disease (GVHD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), and no systemic disease. Corneal/conjunctival fluorescein staining was scored and the correlation between the score and the IL-17 level was evaluated.
RESULTS
A strong correlation existed between IL-17 level and the type of systemic disease. IL-17 was significantly elevated in patients with chronic GVHD compared to those with RA and SS. IL-17 was not detectable in patients with SLE or in those without systemic disease. IL-23 was not detected in any of the subjects. IL-17 was significantly increased in patients with high fluorescein staining scores.
CONCLUSIONS
Our data suggest that IL-17 is involved in the pathogenesis of DE in patients with systemic immune-mediated diseases.

Keyword

Chronic graft-versus-host disease; Dry eye syndromes; Interleukin-17; Rheumatoid arthritis; Sjogren's syndrome

MeSH Terms

Adult
Biological Markers/blood
Conjunctiva/*pathology
Diagnosis, Differential
Dry Eye Syndromes/*blood/diagnosis/immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
*Immunity, Innate
Interleukin-17/*blood
Male
Middle Aged

Figure

  • Fig. 1 Levels of interleukin (IL)-17 in sera from dry eye patients with systemic diseases and dry eye subjects without systemic disease (control). GVHD = graft-versus-host disease; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus.


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