1. Accensi F, Pinton P, Callu P, Abella-Bourges N, Guelfi JF, Grosjean F, Oswald IP. Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J Anim Sci. 2006. 84:1935–1942.
Article
2. Gown AM, Willingham MC. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem. 2002. 50:449–454.
Article
3. Azcona-Olivera JI, Ouyang Y, Murtha J, Chu FS, Pestka JJ. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicol Appl Pharmacol. 1995. 133:109–120.
Article
4. Bergsjø B, Langseth W, Nafstad I, Jansen JH, Larsen HJ. The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs. Vet Res Commun. 1993. 17:283–294.
Article
5. Bradlaw JA, Swentzel KC, Alterman E, Hauswirth JW. Evaluation of purified 4-deoxynivalenol (vomitoxin) for unscheduled DNA synthesis in the primary rat hepatocyte-DNA repair assay. Food Chem Toxicol. 1985. 23:1063–1067.
Article
6. Chen F, Ma Y, Xue C, Ma J, Xie Q, Wang G, Bi Y, Cao Y. The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs. J Vet Sci. 2008. 9:39–44.
Article
7. Coppock RW, Swanson SP, Gelberg HB, Koritz GD, Hoffman WE, Buck WB, Vesonder RF. Preliminary study of the pharmacokinetics and toxicopathy of deoxynivalenol (vomitoxin) in swine. Am J Vet Res. 1985. 46:169–174.
8. Cote LM, Beasley VR, Bratich PM, Swanson SP, Shivaprasad HL, Buck WB. Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. J Anim Sci. 1985. 61:942–950.
Article
9. Dänicke S, Valenta H, Klobasa F, Döll S, Ganter M, Flachowsky G. Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch Anim Nutr. 2004. 58:1–17.
Article
10. Dini L, Pagliara P, Carlà EC. Phagocytosis of apoptotic cells by liver: a morphological study. Microsc Res Tech. 2002. 57:530–540.
Article
11. Drochner W, Schollenberger M, Götz S, Lauber U, Tafaj M, Piepho HP. Subacute effects of moderate feed loads of isolated Fusarium toxin deoxynivalenol on selected parameters of metabolism in weaned growing piglets. J Anim Physiol Anim Nutr (Berl). 2006. 90:421–428.
Article
12. Gelberg HB. McGavin MD, Zachary JF, editors. Alimentary system. Pathologic Basis of Veterinary Disease. 2007. 4th ed. Elsevier: St. Louis;301–391.
13. Goyarts T, Grove N, Dänicke S. Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the
in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig. Food Chem Toxicol. 2006. 44:1953–1965.
Article
14. Ihara T, Sugamata M, Sekijima M, Okumura H, Yoshino N, Ueno Y. Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis. Nat Toxins. 1997. 5:141–145.
Article
15. Königs M, Schwerdt G, Gekle M, Humpf HU. Effects of the mycotoxin deoxynivalenol on human primary hepatocytes. Mol Nutr Food Res. 2008. 52:830–839.
Article
16. Li M, Cuff CF, Pestka J. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Toxicol Sci. 2005. 87:134–145.
Article
17. Mikami O, Muneta Y, Mori Y, Yokomizo Y, Nakajima Y. Expression of proinflammatory cytokine mRNA in the lymphatic organs of adult and neonatal pigs. Vet Immunol Immunopathol. 2002. 90:203–207.
Article
18. Mikami O, Yamamoto S, Yamanaka N, Nakajima Y. Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. Toxicology. 2004. 204:241–249.
Article
19. Nakajima Y, Momotani E, Takahashi H, Ishikawa Y, Ito T, Kanesaki M, Madarame H. Endogenous tumor necrosis factor (TNF) production and modification of pathological lesions in experimental
Escherichia coli endotoxemia of piglets. Vet Immunol Immunopathol. 1995. 45:45–54.
Article
20. Pestka JJ. Mechanisms of deoxynivalenol-induced gene expression and apoptosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008. 25:1128–1140.
Article
21. Pestka JJ, Tai JH, Witt MF, Dixon DE, Forsell JH. Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone. Food Chem Toxicol. 1987. 25:297–304.
Article
22. Pestka JJ, Yan D, King LE. Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells. Food Chem Toxicol. 1994. 32:1125–1136.
Article
23. Pestka JJ, Zhou HR, Moon Y, Chung YJ. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol Lett. 2004. 153:61–73.
Article
24. Pestka JJ, Smolinski AT. Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Environ Health B Crit Rev. 2005. 8:39–69.
Article
25. Pinton P, Accensi F, Beauchamp E, Cossalter AM, Callu P, Grosjean F, Oswald IP. Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicol Lett. 2008. 177:215–222.
Article
26. Prelusky DB, Trenholm HL. Tissue distribution of deoxynivalenol in swine dosed intravenously. J Agric Food Chem. 1991. 39:748–751.
Article
27. Prelusky DB, Gerdes RG, Underhill KL, Rotter BA, Jui PY, Trenholm HL. Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig. Nat Toxins. 1994. 2:97–104.
Article
28. Resendes AR, Majó N, Segalés J, Espadamala J, Mateu E, Chianini F, Nofrarías M, Domingo M. Apoptosis in normal lymphoid organs from healthy normal, conventional pigs at different ages detected by TUNEL and cleaved caspase-3 immunohistochemistry in paraffin-embedded tissues. Vet Immunol Immunopathol. 2004. 99:203–213.
Article
29. Rothkötter HJ, Sowa E, Pabst R. The pig as a model of developmental immunology. Hum Exp Toxicol. 2002. 21:533–536.
Article
30. Rotter BA, Prelusky DB, Pestka JJ. Toxicology of deoxynivalenol (vomitoxin). J Toxicol Environ Health. 1996. 48:1–34.
31. Sahu SC, Garthoff LH, Robl MG, Chirtel SJ, Ruggles DI, Flynn TJ, Sobotka TJ. Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol. J Appl Toxicol. 2008. 28:765–772.
Article
32. Sugita-Konishi Y, Hara-Kudo Y, Kasuga F, Kumagai S. Effect of trichothecenes on host defense against infectious diseases. Mycotoxins. 1998. 47:19–23.
33. Sun XM, Zhang XH, Wang HY, Cao WJ, Yan X, Zuo LF, Wang JL, Wang FR. Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro. Biomed Environ Sci. 2002. 15:145–152.
34. Tiemann U, Brüssow KP, Küchenmeister U, Jonas L, Kohlschein P, Pöhland R, Dänicke S. Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts. Food Chem Toxicol. 2006. 44:1228–1235.
Article
35. Trenholm HL, Hamilton RM, Friend DW, Thompson BK, Hartin KE. Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle. J Am Vet Med Assoc. 1984. 185:527–531.
36. Young LG, McGirr L, Valli VE, Lumsden JH, Lun A. Vomitoxin in corn fed to young pigs. J Anim Sci. 1983. 57:655–664.
Article
37. Zhou HR, Harkema JR, Hotchkiss JA, Yan D, Roth RA, Pestka JJ. Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. Toxicol Sci. 2000. 53:253–263.
Article
38. Zhou HR, Islam Z, Pestka JJ. Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. Toxicol Sci. 2003. 72:130–142.
Article
39. Zhou HR, Yan D, Pestka JJ. Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course. Toxicol Appl Pharmacol. 1997. 144:294–305.
Article