Exp Mol Med.  2011 Jun;43(6):323-333. 10.3858/emm.2011.43.6.034.

Phenylpropanoids in radioregulation: double edged sword

• Kim W
• Seong KM
• Youn B

• KMID: 1107373
• DOI: http://doi.org/10.3858/emm.2011.43.6.034

Abstract

Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

Keyword

phenylpropanoids; neoplasm; radiation, ionizing; radiotherapy

MeSH Terms

Antineoplastic Agents/*therapeutic use
Apoptosis/drug effects/radiation effects
Chromones/therapeutic use
Combined Modality Therapy
Cytoprotection/drug effects/radiation effects
Humans
Neoplasms/pathology/*radiotherapy
Phenylpropionates/therapeutic use
Plants
Radiation Tolerance/drug effects
Radiation-Sensitizing Agents/*therapeutic use
*Radiotherapy