J Vet Sci.  2008 Dec;9(4):433-435. 10.4142/jvs.2008.9.4.433.

Efficiency of Matricaria chamomilla CH(12) and number of doses of rabies vaccine on the humoral immune response in cattle

  • 1Universidade do Oeste Paulista-UNOESTE, Pos-graducao em Ciencia Animal, Presidente Prudente-SP, CEP 19067-175, Brazil. reis.lsls@gmail.com
  • 2Secao de Raiva do Instituto Butantan, Sao Paulo-SP, CEP 05503-900, Brazil.
  • 3Universidade do Oeste Paulista, UNOESTE, Laboratorio de Medicina Veterinaria Preventiva, Presidente Prudente-SP, CEP 19067-175, Brazil.
  • 4Agencia Paulista de Tecnologia dos Agronegocios, Presdente Prudente, Sao Paulo, CEP 19100-000, Brazil.
  • 5Universidade Estadual Paulista Julio de Mesquita Filho-UNESP/FMVZ, Departamento de Reproducao Animal e Radiologia, Botucatu, Sao Paulo, CEP 18618-000, Brazil.


This study evaluated the effect of Matricaria chamomilla and vaccination frequency on cattle immunization against rabies. Four groups (n = 15 /group) were treated with or without Matricaria chamomilla CH(12) and vaccinated with one or two doses of rabies vaccine (30 day interval). No effect of chamomile was found on cattle immunization against rabies; however, antibody titers were protective in cattle vaccinated twice, while 93.3% of cattle vaccinated only once had titers under 0.5 UI/ml after 60 days. In conclusion, the use of chamomile did not alter the humoral immune response in cattle, and two vaccine doses are suggested for achieving protective antibody titers.


cattle; immune response; Matricaria chamomilla; rabies; vaccine
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