J Vet Sci.  2008 Dec;9(4):433-435. 10.4142/jvs.2008.9.4.433.

Efficiency of Matricaria chamomilla CH(12) and number of doses of rabies vaccine on the humoral immune response in cattle

• de Souza Reis LS
• Frazatti-Gallina NM
• de Lima Paoli R
• Giuffrida
• Albas A
• Oba E
• Pardo PE

• KMID: 1104922
• DOI: http://doi.org/10.4142/jvs.2008.9.4.433

Abstract

This study evaluated the effect of Matricaria chamomilla and vaccination frequency on cattle immunization against rabies. Four groups (n = 15 /group) were treated with or without Matricaria chamomilla CH(12) and vaccinated with one or two doses of rabies vaccine (30 day interval). No effect of chamomile was found on cattle immunization against rabies; however, antibody titers were protective in cattle vaccinated twice, while 93.3% of cattle vaccinated only once had titers under 0.5 UI/ml after 60 days. In conclusion, the use of chamomile did not alter the humoral immune response in cattle, and two vaccine doses are suggested for achieving protective antibody titers.

Keyword

cattle; immune response; Matricaria chamomilla; rabies; vaccine

MeSH Terms

Animals
Antibodies, Viral/blood
Cattle
Dose-Response Relationship, Immunologic
Drug Administration Schedule
Drug Interactions
Matricaria/*chemistry
Plant Extracts/chemistry/*pharmacology
Rabies Vaccines/administration & dosage/*immunology

Figure

• 

  Fig. 1 Mean rabies-neutralizing antibody titers from Nelore cattle on days 30 and 60. Cattle from groups FEV1 and FEV2 received Matricaria chamomilla CH12 mixed with the mineral salt and were vaccinated with one and two doses of rabies vaccine, respectively. Cattle from groups V1 and V2 had only mineral salt and one and two doses of rabies vaccine, respectively. An asterisk (*) indicates significant statistical difference between observation days 30 and 60 within each group. In 30 days, letter A means statistical non-significant among all groups. In 60 days, letter A and B means statistical significant between vaccination and non-vaccination all group, respectively.

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