Korean J Ophthalmol.  2006 Jun;20(2):99-103. 10.3341/kjo.2006.20.2.99.

Triamcinolone-Induced Intraocular Pressure Elevation: Intravitreal Injection for Macular Edema and Posterior Subtenon Injection for Uveitis

• Jea SY
• Byon IS
• Oum BS

• KMID: 1099043
• DOI: http://doi.org/10.3341/kjo.2006.20.2.99

Abstract

PURPOSE: To assess the effect of intravitreal and posterior subtenon injections of triamcinolone acetonide (TA) on intraocular pressure (IOP). METHODS: we reviewed 42 consecutive eyes after intravitreal TA injection (IVTA) and 43 eyes following posterior subtenon TA injection (PSTA). All cases had a minimum follow-up time of three months. After injection, the value and time of the maximal IOP, the amount of IOP elevation and the needs of the medication were assessed. RESULTS: The IOP increased significantly (p<0.001) from 16.3+/-2.5 mmHg preoperatively to a mean maximum of 21.7+/-5.3 mmHg in the IVTA group, and from 15.3+/-4.5 mmHg to 20.6+/-3.0 mmHg in the PSTA group. An elevation in the IOP of more than 5 mmHg from the baseline IOP was seen in 52.4% of the IVTA group at a mean time of 3.1 weeks postoperatively, and 44.2% of the PSTA group displayed an IOP elevation at 5.9 weeks. CONCLUSIONS: Both developed significant elevations of IOP, but this appeared at a later date in the PSTA group. Careful follow-up after local injection of steroids is necessary.

Keyword

Intraocular pressure; Intravitreal injection; Subtenon injection; Triamcinolon acetonide

MeSH Terms

Vitreous Body
Uveitis, Posterior/*drug therapy/pathology
Triamcinolone Acetonide/administration & dosage/*adverse effects
Time Factors
Retrospective Studies
Orbit
Ocular Hypertension/*chemically induced/physiopathology
Middle Aged
Male
Macular Edema, Cystoid/*drug therapy/pathology
Intraocular Pressure/*drug effects
Injections
Humans
Glucocorticoids/administration & dosage/*adverse effects
Follow-Up Studies
Female
Aged, 80 and over
Aged
Adult