Yonsei Med J.  1961 Dec;2(1):48-51. 10.3349/ymj.1961.2.1.48.

Pathology of Ruptured Saccular Aneurysms of Cerebral Arteries Causing Sudden Death

  • 1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.


Fibrinoid necrosis of arterial walls, apparently of a primary nature, occurs quite frequently in the saccular aneurysms of cerebral arteries. A careful analysis of 25 cases of ruptured saccular aneurysms of cerebral arteries causing sudden death was made. All cases selected represented only the ones who had died instantly in public or whose instant death could be verified, in order to eliminate possible secondary necrosis. In 18 cases, genuine fibrinoid necrosis was observed involving all or parts of the aneurysmal walls. This furnishes an interesting speculation as to the pathogenesis of rupture in such aneurysms. An additional attempt is made during the course of this study on the pathogenesis of saccular aneurysm itself to reveal abnormalities in the elastic fibers to be the primary cause for such aneurysm formation. Other possible mechanisms are also discussed.

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