J Vet Sci.
2005 Sep;6(3):259-261.
Color-dilution alopecia in dogs
- Affiliations
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- 1Department of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea. kimjhoon@cheju.ac.kr
- 2College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA.
- 3National Veterinary Research and Quarantine Service, Mnistry of Agriculture and Forestry, Anyang 430-824, Korea.
- 4Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
- 5Department of Animal Science, College of Life Science and Natural Resources, Sangji University, Wonju 220-702, Korea.
Abstract
- Color-dilution alopecia is a relatively uncommon hereditary skin disease seen in "Blue" and other color-diluted dogs. This syndrome is associated with a color-dilution gene. The initial clinical signs are the gradual onset of a dry, dull and poor hair coat quality. Hair shafts and hair regrowth are poor, and follicular papules may develop and progress to frank comedones. Hair loss and comedo formation are usually most severe on the trunk, especially color-diluted area on the skin. Six cases of color-dilution alopecia are reported in 3 months to 10 years old dogs. The breeds of dogs are blue Doberman Pinscher, Miniature Pinscher, Dachshund, and Schnauzer. Grossly, extensive partial hair loss was seen on the skin. Histopathologically, the epidermis is relatively normal but may be hyperplastic. Hair follicles are characterized by atrophy and distortion. Heavily clumped melanin is present in the epidermis, dermis and hair follicles.
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