J Vet Sci.  2006 Sep;7(3):299-301. 10.4142/jvs.2006.7.3.299.

Canine renal failure syndrome in three dogs

• Jeong WI
• Do SH
• Jeong DH
• Chung JY
• Yang HJ
• Yuan DW
• Hong IH
• Park JK
• Goo MJ
• Jeong KS

• KMID: 1089918
• DOI: http://doi.org/10.4142/jvs.2006.7.3.299

Abstract

Three dead dogs were brought to the College of Veterinary Medicine, Kyungpook National University for study. Clinically, all the dogs showed emaciation, anorexia, depression, hemorrhagic vomiting and diarrhea for 7~10 days before death. All the clinical signs were first noted for about one month after feeding the dogs with commercial diets. At necropsy, all 3 dogs had severe renal damage with the same green-yellowish colored nephroliths in the renal pelvis. They also showed systemic hemorrhage and calcification of several organs, which might have been induced by uremia. Microscopically, necrosis, calcification and calculi were detected in the renal tubules, and especially in the proximal convoluted tubules and collecting ducts of the kidney. These findings were supportive of a mycotoxic effect, and especially on their kidneys. However, the precise cause of the toxic effect in these cases of canine renal failure could not be determined.

Keyword

canine renal failure syndrome; fungal toxin; kidney; nephrolith

MeSH Terms

Animals
Dog Diseases/microbiology/*pathology
Dogs
Fatal Outcome
Female
Histocytochemistry/veterinary
Kidney Failure, Acute/microbiology/pathology/*veterinary
Male
Mycotoxicosis/microbiology/pathology/*veterinary

Figure

• 

  Fig. 1 Kidney of a dog. a (case No. 1.); Nephroliths (arrow) with green-yellow color in the pelvis, and hemorrhage spots (arrow head) are found in both kidney. b (case No. 1.); Severe calcification in the tubules of the cortex and hemorrhage. c (case No. 2); Necrosis of the proximal convoluted tubules and protein casts in the lumen of the tubules, including calcification in the basement membrane. d (case No. 2); Calcium and green-yellow crystals (arrow) are deposited in the tubules of the cortex. H&E stain, Scale bars for b & c; 50 µm, d; 25 µm.

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