J Vet Sci.  2006 Sep;7(3):229-232. 10.4142/jvs.2006.7.3.229.

Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats

• Jegede OC
• Ajanusi JO
• Adaudi AO
• Agbede RI

• KMID: 1089906
• DOI: http://doi.org/10.4142/jvs.2006.7.3.229

Abstract

Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic activity against an experimental Nippostrongylus braziliensis infection in rats. Acute oral toxicity occurred at a dose of 1,140 mg/kg, while anthelmintic trials against Nippostrongylus braziliensis in rats using the aqueous fraction showed a progressive decrease in worm count with increasing dose (10, 13, 16, 20 and 25 mg per kg body weight) (p < 0.05). At 25 mg per kg body weight, the worm count was significantly lower than that at 10 mg per kg body weight (p < 0.05).

Keyword

anthelmintic; Spigelia anthelmia; Nippostrongylus braziliensis

MeSH Terms

Animals
Anthelmintics/*pharmacology/toxicity
Drug Evaluation, Preclinical
Lethal Dose 50
Loganiaceae/*chemistry
Medicine, African Traditional
Nigeria
Nippostrongylus/*growth&development
Phytotherapy/*methods
Plant Extracts/*pharmacology/toxicity
Rats
Rats, Wistar
Strongylida Infections/*drug therapy/parasitology

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