J Vet Sci.  2003 Aug;4(2):187-191.

Immobilization with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus Monkeys

• Lee JI
• Hong SH
• Lee SJ
• Kim YS
• Kim MC

Abstract

To compare the effects of ketamine and tiletaminezolazepam (TZ) drugs widely used for the chemical restraint and immobilization of primates, on various physiological parameters and blood gas values in cynomolgus monkeys (Macaca facicularis). Rectal temperature, heart rate, respiration rate and blood gas analysis were measured before treatment and at 1, 10, 20, 30, 40, 50 and 60 min after administration. Additionally, in both groups, induction and maintenance times were compared. Heart rate, respiration rate, rectal temperature, pH and pCO2 were not significant different in the two groups. However, pO2 in the ketamine-treated group was significantly lower at 30 and 40 min than in the TZ-treated group. The induction time was short in both groups, and the maintenance time was longer in the TZ-treated group (67.8+/-6.5 min) than in the ketamine-treated group (42.3+/-6.7 min). However, decreased rectal temperatures must be watched and prevented following TZ administration to cynomolgus monkeys. It was considered that ketamine may be useful for short duration anesthesia including handling, physical examination, blood sampling and TZ may be useful for prolonged anesthesia including minor surgery and other surgical procedure.

MeSH Terms

Animals
Body Temperature/drug effects
Carbon Dioxide/blood
Excitatory Amino Acid Antagonists/*pharmacology
Female
Heart Rate/drug effects
Hydrogen-Ion Concentration
Immobilization/*physiology
Ketamine/*pharmacology
Macaca fascicularis
Male
Partial Pressure
Respiratory Mechanics
Restraint, Physical/*methods
Tiletamine/*pharmacology
Time Factors