J Korean Med Sci.  2003 Dec;18(6):842-848. 10.3346/jkms.2003.18.6.842.

Hepatocyte Expressions in Hepatocellular Carcinomas, Gastrointestinal Neoplasms, and Non-neoplastic Gastrointestinal Mucosa: its Role as a Diagnostic Marker

• Lee HS
• Kim WH
• Kang GH

• KMID: 1086741
• DOI: http://doi.org/10.3346/jkms.2003.18.6.842

Abstract

We performed immunohistochemical staining against Hepatocyte (Hep) and CD10 antibodies in 75 hepatocellular carcinoma (HCC), 50 cholangiocarcinomas, 49 colorectal adenocarcinomas, and 308 gastric adenocarcinomas by tissue array method. We also evaluated the various non-neoplastic adult tissues and fetal digestive organs. Hep was expressed in 80% of HCCs, and HCCs without Hep expression were more likely to have a higher Edmondson & Steiner grade than HCCs with Hep expression (p=0.004). In non-HCCs, 16% of cholangiocarcinomas, 8.2% of colorectal carcinomas, and 44.2% of gastric carcinomas expressed Hep. Gastric carcinomas with Hep expression were significantly associated with early gastric carcinomas (p<0.001). In non-neoplastic tissues, Hep was found expressed in normal hepatocytes, small intestinal mucosa, and intestinal metaplasia of the stomach. Fetal hepatocytes expressed Hep after 19 weeks of gestation. CD10 was detected in 46.7% (35/75) of HCCs, and canalicular staining pattern was predominant in HCCs. In conclusion, the expression of Hep and CD10 may help to distinguish HCCs from non-HCCs.

Keyword

Carcinoma; Hepatocellular; Hepatocytes; Hepatocyte-Paraffin 1; CD10 Antigen; Immunohistochemistry

MeSH Terms

Adult
Antibodies, Monoclonal/metabolism
Carcinoma, Hepatocellular/*metabolism/pathology
Diagnosis, Differential
Epitopes
Gastric Mucosa/cytology/*metabolism
Gastrointestinal Neoplasms/*metabolism/pathology
Hepatocytes/cytology/*metabolism
Human
Immunohistochemistry
Intestinal Mucosa/cytology/*metabolism
Liver Neoplasms/*metabolism/pathology
Neprilysin/metabolism
Support, Non-U.S. Gov't
Tumor Markers, Biological