J Korean Med Sci.  1997 Apr;12(2):157-159. 10.3346/jkms.1997.12.2.157.

Renal potassium wasting and hypocalciuria ameliorated with magnesium repletion in Gitelman's syndrome

Affiliations
  • 1Department of Internal Medicine, Hanyang University Kuri Hospital, Korea.

Abstract

A woman aged 45 years was presented with hypokalemic metabolic alkalosis and hypomagnesemia associated with renal potassium and magnesium wasting. Her 24-hour urinary calcium excretion was strikingly low despite normocalcemia and normal creatinine clearance, which is one of characteristic findings of Gitelman's syndrome (GS). She was evaluated for the responses following Mg supplementation for 10 days, which showed marked increments in serum potassium and magnesium as well as improvements of the degree of renal potassium wasting and hypocalciuria. This amelioration of abnormal biochemical pictures in this patient after Mg supplementation proposes that the hypokalemia with renal potassium wasting and hypocalciuria may be caused by abnormal Mg metabolism.


MeSH Terms

Bartter's Disease/urine
Bartter's Disease/therapy*
Bartter's Disease/blood
Calcium/urine*
Case Report
Female
Food, Fortified
Human
Hypokalemia/therapy*
Magnesium/blood*
Middle Age
Syndrome
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