J Korean Med Sci.  2001 Feb;16(1):115-118. 10.3346/jkms.2001.16.1.115.

Spontaneous acute tumor lysis syndrome with advanced gastric cancer

• Woo IS
• Kim JS
• Park MJ
• Lee MS
• Cheon RW
• Chang HM
• Ahn JS
• Lee JA
• Park YI
• Park YS
• Shim JW
• Yang I

• KMID: 1066505
• DOI: http://doi.org/10.3346/jkms.2001.16.1.115

Abstract

Acute tumor lysis syndrome (TLS) occurs frequently in hematologic malignancies such as high-grade lymphomas and acute leukemia, which are rapidly proliferating and chemosensitive tumors. It occurs rarely in solid tumors and has never been reported in gastric adenocarcinoma. Typical biochemical findings of acute tumor lysis syndrome are hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia in patients with a malignancy. Rapid changes of these electrolytes may cause cardiac arrhythmia, seizure, acute renal failure and sudden death. Therefore, as soon as it is detected, it should be taken care of immediately. Until now almost all cases of TLS associated with solid tumor have developed after cytoreductive therapy in chemosensitive tumors. We report here a case of spontaneous acute tumor lysis in a patient of advanced gastric cancer with hepatic metastases and multiple lymphadenopathy. The biochemical finding of TLS improved with the management and tumor burden also showed slight response to the one cycled combination chemotherapy but the patient died of progressive pneumonia.

Keyword

Tumor Lysis Syndrome; Stomach Neoplasms; Solid Tumor

MeSH Terms

Acute Disease
Adult
Case Report
Human
Male
Stomach Neoplasms/pathology
Stomach Neoplasms/drug therapy
Stomach Neoplasms/complications*
Tumor Lysis Syndrome/therapy*