J Vet Sci.  2006 Jun;7(2):199-201. 10.4142/jvs.2006.7.2.199.

Mediastinal lymphoma in a young Turkish Angora cat

• Seo KW
• Choi US
• Bae BK
• Park MS
• Hwang CY
• Kim DY
• Youn HY

• KMID: 1059209
• DOI: http://doi.org/10.4142/jvs.2006.7.2.199

Abstract

An 8-month old intact male Turkish Angora cat was referred to the Veterinary Medical Teaching Hospital (VMTH), Seoul National University, for an evaluation of anorexia and severe dyspnea. The thoracic radiographs revealed significant pleural effusion. A cytology evaluation of the pleural fluid strongly suggested a lymphoma containing variable sized lymphocytes with frequent mitotic figures and prominent nucleoli. The feline leukemia virus and feline immunodeficiency virus tests were negative. The cat was euthanized at his owner's request and a necropsy was performed. A mass was detected on the mediastinum and lung lobes. A histopathology evaluation confirmed the mass to be a lymphoma. Immunohistochemistry revealed the mass to be CD3 positive. In conclusion, the cat was diagnosed as a T-cell mediastinal lymphoma.

Keyword

feline; immunohistochemistry; mediastinal lymphoma; T-cell; Turkish Angora cat

MeSH Terms

Animals
Cat Diseases/*diagnosis/pathology
Cats
Lymphoma/diagnosis/pathology/*veterinary
Male
Mediastinal Neoplasms/diagnosis/pathology/*veterinary

Figure

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  Fig. 1 Cytologic smear of pleural effusion of the cat. Note the neoplastic large lymphocytes with the diameter of nuclei more than 3 times that of RBC and a large central nucleolus. There is one mitotic figure in the center. Wright stain, ×100.

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  Fig. 2 Gross lesion of the large mass from thorax necropsy of a cat diagnosed mediastinal lymphoma. Note the abnormal large mass around the heart instead of normal lung structures.

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  Fig. 3 Histological section of feline mediastinal mass, diagnosed as a mediastinal lymphoma. Note compact sheet of monomorphic lymphoid cells. H&E stain, ×150.

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  Fig. 4 Immunohistochemical staining for CD3 detection of feline mediastinal lymphoma. ×40.

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