Korean J Radiol.  2012 Feb;13(1):94-97. 10.3348/kjr.2012.13.1.94.

Pancreatic Islet Cell Amyloidosis Manifesting as a Large Pancreas

Affiliations
  • 1Department of Radiology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119. ruhionur@yahoo.com
  • 2Department of Gastroenterology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119.
  • 3Department of Pathology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119.
  • 4Department of Endocrinology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119.

Abstract

A 39-year-old female patient presented to our hospital with epigastric pain lasting for two months. Laboratory results showed impaired glucose tolerance. Ultrasonography of the patient showed a hypoechoic, diffusely enlarged pancreas. CT revealed a large pancreas, with multiple calcifications. On MRI, a diffusely enlarged pancreas was seen hypointense on both T1- and T2-weighted images with heterogeneous enhancement after gadolinium administration. A biopsy of the pancreas revealed primary amyloidosis of islet cells. Decreased signal on T1-weighted images without inflammation findings on CT and MRI were clues for the diagnosis.

Keyword

Pancreas; Amyloidosis; Ultrasonography; Computed tomography; Magnetic resonance imaging

MeSH Terms

Adult
Amyloidosis/*diagnosis
Contrast Media/diagnostic use
Diagnosis, Differential
*Diagnostic Imaging
Female
Glucose Tolerance Test
Humans
Islets of Langerhans/*pathology
Pancreatic Diseases/*diagnosis
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