Korean J Ophthalmol.  2003 Dec;17(2):83-90. 10.3341/kjo.2003.17.2.83.

Effects of viscoelastic material on the corneal endothelial cells in trabeculectomy with adjunctive mitomycin-C

• Shin DB
• Lee SB
• Kim CS

• KMID: 1037762
• DOI: http://doi.org/10.3341/kjo.2003.17.2.83

Abstract

We evaluated the change of corneal endothelium after trabeculectomy with mitomycin-C soaking (0.2 mg/ml, 2.4 +/- 1.2 minutes) and the effect of viscoelastic material in reducing this change. In randomly selected cases, 0.05 ml of sodium hyaluronate (Healon) was injected into anterior chamber (Healon group, n = 20), and same amount of balanced salt solution was injected in the other eyes (Control, n = 18) at the beginning of surgery. There were no differences in clinical variables and specular microscopy result between 2 groups before surgery. After surgery, the change of endothelial cells were significantly reduced in Healon group (cell density; -2.5 +/- 1.6%, variability of cell area; 5.8 +/- 2.5%, and percentage of hexagonal cell; -2.2 +/- 0.7%) compared to control group (-7.7 +/- 6.0%, 8.9 +/- 4.4%, and -4.8 +/- 3.5% respectively, p < 0.01). In trabeculectomy with mitomycin-C, the damage to the corneal endothelium was reduced significantly by injecting the viscoelastic material without significant complication.

MeSH Terms

Adjuvants, Immunologic/administration & dosage*
Adjuvants, Immunologic/chemistry
Administration, Topical
Adult
Aged
Antimetabolites/administration & dosage*
Drug Therapy, Combination
Elasticity
Endothelium, Corneal/drug effects*
Endothelium, Corneal/pathology
Female
Glaucoma/surgery*
Human
Hyaluronic Acid/administration & dosage*
Hyaluronic Acid/chemistry
Intraoperative Care
Male
Middle Aged
Mitomycin/administration & dosage*
Retrospective Studies
Trabeculectomy*
Viscosity