Korean J Hepatol.  2011 Sep;17(3):229-232. 10.3350/kjhep.2011.17.3.229.

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage

Affiliations
  • 1Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. 93cool@hanmail.net
  • 2Department of Pathology, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

Abstract

Amoxicillin, an antibiotic that is widely prescribed for various infections, is associated with a very low rate of drug-induced liver injury; hepatitis and cholestasis are rare complications. Here we present a case of a 39-year-old woman who was diagnosed with abdominal actinomycosis and received amoxicillin treatment. The patient displayed hepatocellular and bile-duct injury, in addition to elevated levels of liver enzymes. The patient was diagnosed with amoxicillin-induced cholestatic hepatitis. When amoxicillin was discontinued, the patient's symptoms improved and her liver enzyme levels reduced to near to the normal range.

Keyword

Drug-induced liver injury; Amoxicillin; Cholestatic hepatitis

MeSH Terms

Actinomycosis/drug therapy
Adult
Alanine Transaminase/blood
Alkaline Phosphatase/blood
Amoxicillin/*adverse effects
Anti-Bacterial Agents/*adverse effects
Aspartate Aminotransferases/blood
Cholestasis/*chemically induced
Drug-Induced Liver Injury/*diagnosis/etiology
Female
Humans
Liver/enzymology
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