Korean J Intern Med.  2011 Sep;26(3):348-351. 10.3904/kjim.2011.26.3.348.

Primary Adenosquamous Cell Carcinoma of the Pancreas: A Case Report with a Review of the Korean Literature

Affiliations
  • 1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. kwchung@ewha.ac.kr
  • 2Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea.

Abstract

The most common pancreatic cancer is adenocarcinoma. Primary adenosquamous cell carcinoma of the pancreas is very rare and aggressive. A 46-year-old man presented with a 3-month history of dyspepsia and a 7-kg weight loss. The physical examination showed tenderness of the right upper quadrant of the abdomen. There was no jaundice. Amylase and lipase were elevated. CA 19-9 was elevated to 566.7 U/mL. Gastroduodenoscopy showed a hard ulceroinfiltrative mass with a yellowish exudate that bled readily on touch in the second portion of the duodenum. Abdominal computed tomography showed a 7.1 x 6.3-cm heterogeneously enhancing mass in the pancreatic head. The pancreatic mass had invaded the duodenum wall, gastric antrum, and gastroduodenal artery sheath. Fine-needle aspiration biopsy of the pancreatic mass revealed adenosquamous cell carcinoma, anaplastic type. We concluded that an adenosquamous cell carcinoma of pancreas had invaded the duodenal mucosa causing ulceration.

Keyword

Pancreas; Carcinoma, Adenosquamous

MeSH Terms

Amylases/blood
Biopsy, Fine-Needle
CA-19-9 Antigen/blood
Carcinoma, Adenosquamous/blood/complications/*diagnosis/pathology
Duodenoscopy
Duodenum/pathology
Humans
Intestinal Mucosa/pathology
Lipase/blood
Male
Middle Aged
Neoplasm Invasiveness
Pancreatic Neoplasms/blood/complications/*diagnosis/pathology
Tomography, X-Ray Computed
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