Korean J Obstet Gynecol.  2004 Jan;47(1):109-117.

Comparison of Efficacy between MonoPrep(R) and Papanicolaou Smear for Cervical Cancer Screening

  • 1Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
  • 2Department of Pathology, Ajou University School of Medicine, Suwon, Korea.


To compare the specimen adequacy and cytologic diagnostic results of MonoPrep(R), a type of liquid based preparation, with the conventional Pap smear.
In randomly selected 156 patients who visited the department of Obstetrics and Gynecology, Ajou University Hospital for cervical biopsy, conventional Pap smear and matched MonoPrep(R) were performed. Statistical analysis was performed with chi-square test.
There were more "Unsatisfactory" and "Satisfactory but limited by (SBLB)" results in the conventional Pap smear group, even though no statistical significance could be found between the two groups. ASC/LSIL ratio was significantly decreased in the MonoPrep(R) group, showing 0.4 with MonoPrep(R) and 1.9 with conventional Pap smear demonstrating a 78.4% decrease (P<0.001). In detecting abnormal cervical lesions, conventional pap smear showed a sensitivity of 87.7%, positive predictability of 82.3%, false negativity of 10.3%, while MonoPrep(R) showed a sensitivity of 94.8% (P=0.04), positive predictability of 97.4% (P<0.001), and false negativity of 2.6% (P=0.016).
MonoPrep(R) is more effective for the detection of cervical lesions with higher sensitivity and lower false negativity compared to conventional pap smear.


MonoPrep(R); Liquid based preparation; Sensitivity; False negativity
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