Korean J Ophthalmol.  2012 Jun;26(3):163-168. 10.3341/kjo.2012.26.3.163.

Age and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography

Affiliations
  • 1Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.
  • 2Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea. brainh@hanmail.net
  • 3Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.
  • 4Department of Radiation Oncology, Korea University College of Medicine, Seoul, Korea.
  • 5Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
To evaluate the association between age and peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) spectral domain optical coherence tomography (OCT) in healthy Korean subjects.
METHODS
A total of 302 eyes from 155 healthy Korean subjects (age range, 20 to 79 years) underwent RNFL thickness measurements using the Cirrus HD-OCT. Average, quadrant, and clock-hour RNFL thickness parameters were analyzed in terms of age using linear mixed effect models.
RESULTS
Average RNFL demonstrated a slope of -2.1 microm per decade of age (p < 0.001). In quadrant analysis, superior (-3.4 microm/decade, p < 0.001) and inferior (-2.9 microm/decade, p < 0.001) quadrants showed steeper slopes, whereas temporal (-1.1 microm/decade, p < 0.001) and nasal (-1.0 microm/decade, p < 0.001) quadrants revealed shallower slopes. Among the 12 clock-hour sectors, clock hours 6 (-4.5 microm/decade, p < 0.001) and 1 (-4.1 microm/decade, p < 0.001) showed the greatest tendency to decline with age; RNFLs of the 3 (-0.2 microm/decade, p = 0.391) and 4 (-0.6 microm/decade, p = 0.052) o'clock hour sectors did not show significant decay.
CONCLUSIONS
RNFL thickness was associated with age, especially in superior and inferior areas. The topographic distribution of correlation between age and RNFL thickness was not uniform.

Keyword

Aging; Glaucoma; Optical coherence tomography

MeSH Terms

Adult
Aged
*Aging
*Asian Continental Ancestry Group
Humans
Male
Middle Aged
*Nerve Fibers
Reference Values
Reproducibility of Results
Retinal Ganglion Cells/*cytology
Tomography, Optical Coherence/*methods
Young Adult
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