Korean J Dermatol.  2003 Jan;41(1):15-20.

Evaluation of the Anti-inflammatory Effect of a Moisturizer Containing Green-Tea Extracts

Affiliations
  • 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. gcpark@snu.ac.kr
  • 2Welskin Co., Seoul, Korea.

Abstract

BACKGROUND
For the long-term management of chronic dermatitis such as atopic dermatitis or xerotic eczema, it is important for a clinician to choose a medication that has the least side effects. OBJECTIVE: We planned to evaluate the anti-inflammatory effect of a moisturizer containing green-tea extracts compared with 1% hydrocortisone lotion. METHODS: The anti-inflammatory effects of 1% hydrocortisone lotion and a moisturizer containing green-tea extracts were evaluated in the inflammation of skin induced by ultraviolet B(UVB) irradiation and sodium lauryl sulfate(SLS) irritation. Twice a day application of topical agents for reducing artificially induced local inflammation was done. Mexameter and chromameter were used for the evaluation of erythema. RESULTS: UVB induced erythema continued to increase regardless of applying topical agents. In contrast, SLS-induced erythema slowly decreased with time duration. Furthermore, increasing pattern of erythema was irregular after UVB irradiation. These results suggest that SLS-induced erythema was more reliable for evaluation of anti-inflammatory effects of topical agent. In addition, we found that a moisturizer containing green tea extracts showed nearly the same effect as or even more effective than 1% hydrocortisone lotion. CONCLUSION: A moisturizer containing green tea extracts would be effective for improving dry skin and also for the treatment of atopic dermatitis or xerotic eczema.

Keyword

Anti-inflammatory effect; Moisturizer; Green tea extracts

MeSH Terms

Dermatitis
Dermatitis, Atopic
Eczema
Erythema
Hydrocortisone
Inflammation
Skin
Sodium
Tea
Hydrocortisone
Sodium
Tea
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