J Korean Ophthalmol Soc.  2008 Dec;49(12):1901-1909.

Clinical Results After Application of Bevacizumab in Recurrent Pterygium

Affiliations
  • 1Cheil Eye Hospital, Daegu, Korea. eyepark9@dreamwiz.com
  • 2Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, Korea.

Abstract

PURPOSE: To clinically establish the effectiveness and safety of bevacizumab on recurrent pterygium.
METHODS
Twenty patients with recurrent pterygium were given a subconjunctival injection of 0.3 cc bevacizumab, and were evaluated for periodic clinical results at 1 week, 2 weeks, 4 weeks, and every month thereafter. The patients were also evaluated for clinical results and complications.
RESULTS
Of recurrent pterygium patients with bevacizumab injection, the conjunctival injection decreased maximally after 1 to 2 weeks, but significantly increased at 4 weeks (above the lowest level measured at 1 to 2 weeks), and no patient presented conjunctival injection above the pre-injection level at 3 months, except in 2 cases. Two weeks after the injection, ICG anterior segment angiography revealed a significant decrease (30.14+17.69%) in vessel thickness of the pterygium 2 weeks after the bevacizumab injection compared to before the injection. There had been no cases of progression of pterygium, and no ocular or systemic complications due to bevacizumab.
CONCLUSIONS
As shown above in the results, subconjunctival injection of 0.3 cc bevacizumab decreased the conjunctival injection and effectively suppressed any further progression of pterygium. Thus, bevacizumab subconjunctival injection appears to be effective in recurrent pterygium treatment instead of surgical methods.

Keyword

Bevacizumab; Recurrent pterygium; Subconjunctival injection

MeSH Terms

Angiography
Antibodies, Monoclonal, Humanized
Glycosaminoglycans
Humans
Pterygium
Bevacizumab
Antibodies, Monoclonal, Humanized
Glycosaminoglycans
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