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High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils

Seo WJ, Ahn JH, Lee TK, Kim B, Lee JC, Park JH, Yoo YH, Shin MC, Cho JH, Won MH, Park Y

  • Lab Anim Res.
  • 2020 Sep;36(3):229-238.
  • doi: 10.1186/s42826-020-00061-1
Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia...
Estramustine Phosphate Monotherapy in Castration-Resistant Prostate Cancer Patients Who Cannot Receive Cytotoxic Chemotherapy

Ryu JH, Kim SJ, Kim YB, Jung TY, Moon KT, Cho JM, Yoo TK

  • Korean J Urol Oncol.
  • 2020 Aug;18(2):140-146.
  • doi: 10.22465/kjuo.2020.18.2.140
Purpose: To investigate whether estramustine phosphate (EMP) monotherapy is applicable to castration-resistantprostate cancer (CRPC) patients who cannot receive cytotoxic chemotherapy. Materials and Methods: This retrospective single-arm study was conducted in CRPC...
Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test

Shin HC, Lee HB, Yoo TK, Lee ES, Kim RN, Park B, Yoon KA, Park C, Lee ES, Moon HG, Noh DY, Kong SY, Han W

  • Cancer Res Treat.
  • 2020 Jul;52(3):697-713.
  • doi: 10.4143/crt.2019.559
Purpose Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an nextgeneration sequencing (NGS)–based multiple-gene panel...
A Very Low-Positioned Aortic Bifurcation

Degheili JA, Malhas H, Yoo TK, Dergham MYR

  • Vasc Spec Int.
  • 2020 Jun;36(2):112-115.
  • doi: 10.5758/vsi.200009
Anomalies of the aortoiliac arteries are rarely reported and are generally discovered incidentally on imaging performed mostly for investigation of other medical concerns. While aortic bifurcation is typically reported at...
Robotic Simple Prostatectomy: Why and How?

Cho JM, Moon KT, Yoo TK

  • Int Neurourol J.
  • 2020 Mar;24(1):12-20.
  • doi: 10.5213/inj.2040018.009
Increasingly many studies have presented robotic simple prostatectomy (RSP) as a surgical treatment option for large benign prostatic hyperplasia (BPH) weighing 80–100 g or more. In this review, some frequently...
Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer

Jeong YS, Kang J, Lee J, Yoo TK, Kim SH, Lee A

  • J Pathol Transl Med.
  • 2020 Jan;54(1):87-94.
  • doi: 10.4132/jptm.2019.10.14
Background: Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer. The researchers aimed to evaluate the concordance rate...
Potential Benefits of Neoadjuvant Chemotherapy in Clinically Node-Positive Luminal Subtype⁻ Breast Cancer

Kim HS, Yoo TK, Park WC, Chae BJ

  • J Breast Cancer.
  • 2019 Sep;22(3):412-424.
  • doi: 10.4048/jbc.2019.22.e35
PURPOSE: Neoadjuvant chemotherapy (NAC) is less effective for luminal breast cancer because luminal breast cancer has a lower rate of pathological complete response (pCR) after NAC than human epidermal growth...
Magnetic Resonance Imaging Assessment of Blood Flow Distribution in Fenestrated and Completed Fontan Circulation with Special Emphasis on Abdominal Blood Flow

Caro-Dominguez P, Chaturvedi R, Chavhan G, Ling SC, Yim D, Porayette , Lam CZ, Kim TK, Seed M, Grosse-Wortmann L, Yoo SJ

  • Korean J Radiol.
  • 2019 Jul;20(7):1186-1194.
  • doi: 10.3348/kjr.2018.0921
OBJECTIVE: To investigate the regional flow distribution in patients with Fontan circulation by using magnetic resonance imaging (MRI). MATERIALS AND METHODS: We identified 39 children (18 females and 21 males; mean...
Treatment Outcomes of Weakly Positive Hormone Receptor Breast Cancer and Triple-Negative Breast Cancer

Yoon MR, Rhu JY, Song BJ, Chae BJ, Yoo TK

  • J Breast Dis.
  • 2019 Jun;7(1):1-8.
  • doi: 10.14449/jbd.2019.7.1.1
PURPOSE: In breast cancer, response to endocrine therapy depends on estrogen receptor and progesterone receptor status. However, poor prognosis is conferred on patients with hormone receptor (HR)-positive breast cancer. We...
A rare bilateral variation on the dorsum of the hand: extensor digitorum brevis manus and extensor medii proprius

Lee DH, Lee JH, Woo RS, Song DY, Baik TK, Yoo HI

  • Anat Cell Biol.
  • 2019 Mar;52(1):97-99.
  • doi: 10.5115/acb.2019.52.1.97
A 78-year-old male cadaver showed bilateral anomalous muscles on the dorsum of the hand. An extensor digitorum brevis manus was noted on the dorsum of the right hand. It originated...
Omission of Chemotherapy for the Treatment of Mucinous Breast Cancer: A Nationwide Study from the Korean Breast Cancer Society

Kim HS, Lee JU, Yoo TK, Chae BJ, Son D, Kim YJ, Park WC

  • J Breast Cancer.
  • 2019 Dec;22(4):599-612.
  • doi: 10.4048/jbc.2019.22.e46
PURPOSE: Mucinous breast carcinoma (MBC) is a rare type of breast cancer. Although patients with MBC may have a better prognosis than that of patients with invasive ductal carcinoma, many...
Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer

Kim D, Lee J, Kang J, Kim SH, Yoo TK, Oh S, Lee A

  • J Breast Cancer.
  • 2019 Dec;22(4):562-578.
  • doi: 10.4048/jbc.2019.22.e56
PURPOSE: Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results...
Comparison of the Beneficial Effects of Adjuvant Chemotherapy among Young and Old Aged Breast Cancer Patients

Mok S, Yoo TK, Chae BJ

  • J Breast Dis.
  • 2019 Dec;7(2):81-88.
  • doi: 10.14449/jbd.2019.7.2.81
PURPOSE: Breast cancer rates are expected to rise with an increasingly aging society. However, research on breast cancer among elderly women is scarce. In the present study, we aimed to...
Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons

Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS

  • Anat Cell Biol.
  • 2019 Dec;52(4):462-468.
  • doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to...
Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells

Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS

  • Int Neurourol J.
  • 2019 Nov;23(Suppl 2):S111-S118.
  • doi: 10.5213/inj.1938190.095
PURPOSE: Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present...
Poor prognostic factors in human papillomavirus-positive head and neck cancer: who might not be candidates for de-escalation treatment?

Yoo SH, Ock CY, Keam B, Park SJ, Kim TM, Kim JH, Jeon YK, Chung EJ, Kwon SK, Hah JH, Kwon TK, Jung KC, Kim DW, Wu HG, Sung MW, Heo DS

  • Korean J Intern Med.
  • 2019 Nov;34(6):1313-1323.
  • doi: 10.3904/kjim.2017.397
BACKGROUND/AIMS: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not...
Successful removal of permanent spinal cord stimulators in patients with complex regional pain syndrome after complete relief of pain

Lee SJ, Yoo YM, You JA, Shin SW, Kim TK, Abdi S, Kim KH

  • Korean J Pain.
  • 2019 Jan;32(1):47-50.
  • doi: 10.3344/kjp.2019.32.1.47
BACKGROUND: It is uncommon for patients who have received a permanent implant to remove the spinal cord stimulator (SCS) after discontinuation of medication in complex regional pain syndrome (CRPS) due...
Clinical Outcome after Arthroscopic Capsular Release for Adhesive Capsulitis of the Shoulder

Yoo JC, Koh KH, Shon MS, Bae KH, Lim TK

  • Clin Should Elbow.
  • 2018 Sep;21(3):127-133.
  • doi: 10.5397/cise.2018.21.3.127
BACKGROUND: This study was undertaken to evaluate the outcome of the arthroscopic capsular release for adhesive capsulitis of the shoulder. METHODS: This study retrospectively investigated thirty shoulders in 29 patients who...
Thoracic Scoliosis in Patients with Primary Spontaneous Pneumothorax

Lee Y, Kim YJ, Ryu HY, Ku GW, Sung TY, Yoon YS, Kim TK

  • Korean J Thorac Cardiovasc Surg.
  • 2018 Aug;51(4):254-259.
  • doi: 10.5090/kjtcs.2018.51.4.254
BACKGROUND: Primary spontaneous pneumothorax (PSP) affects patients without clinically apparent lung disorder found in tall and thin young male. Scoliosis refers to curves exceeding 10° Cobb angle observed through chest...
Fractionated Stereotactic Radiosurgery for Brain Metastases Using the Novalis Tx® System

Lim TK, Kim WK, Yoo CJ, Kim EY, Kim MJ, Yee GT

  • J Korean Neurosurg Soc.
  • 2018 Jul;61(4):525-529.
  • doi: 10.3340/jkns.2018.0002
OBJECTIVE: To evaluate the efficacy of fractionated stereotactic radiosurgery (FSRS) performed using the Novalis Tx® system (BrainLAB AG, Feldkirchen, Germany; Varian Medical Systems, Palo Alto, CA, USA) for brain metastases. METHODS:...

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