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Fucoidan Induces Apoptosis in A2058 Cells through ROS-exposed Activation of MAPKs Signaling Pathway

Ryu YS, Hyun JW, Chung HS

  • Nat Prod Sci.
  • 2020 Sep;26(3):191-199.
  • doi: 10.20307/nps.2020.26.3.191
Fucoidan, a natural component of brown seaweed, has various biological activities such as anticancer activity, anti-oxidant, and anti-inflammatory against various cancer cells. However, the fucoidan has been implicated in melanoma...
Clinical Outcome of Arthroscopic Partial Repair of Large to Massive Posterosuperior Rotator Cuff Tears: Medialization of the Attachment Site of the Rotator Cuff Tendon

Lee KW, Lee GS, Yang DS, Park SH, Chun YS, Choy WS

  • Clin Orthop Surg.
  • 2020 Sep;12(3):353-363.
  • doi: 10.4055/cios19126
Background: The goal of this study was to evaluate the clinical and radiological outcomes of arthroscopic partial repair with medialization of the attachment site of the rotator cuff tendon and...
Therapeutic Effect of Levodopa/Carbidopa/Entacapone on Sleep Disturbance in Patients with Parkinson’s Disease

Park KW, Jo S, Lee SH, Hwang YS, Lee D, Ryu HS, Chung SJ

  • J Mov Disord.
  • 2020 Sep;13(3):205-212.
  • doi: 10.14802/jmd.20055
Objective To investigate the efficacy of levodopa/carbidopa/entacapone (LCE) at bedtime for treating sleep disturbance in patients with Parkinson’s disease (PD) with motor fluctuations. Methods Participants included 128 PD patients with motor...
Proton pump inhibitor use is associated with hip fracture development: a nationwide populationbased cohort study

Min YW, Lee YC, Kim K, Ryu S, Hong KS, Jeon H, Kim YS, Park JH, Son HJ, Rhee PL

  • Korean J Intern Med.
  • 2020 Sep;35(5):1084-1093.
  • doi: 10.3904/kjim.2018.331
Background/Aims: Effect of proton pump inhibitor (PPI) use on the risk of hip fracture is controversial. This study aimed to clarify the association between PPI use and hip fracture risk using a...
A Universal Screening Strategy for SARS-CoV-2 Infection in Intensive Care Units: Korean Experience in a Single Hospital

Chang E, Choi JS, Park TY, Kim SBK, Ko S, Kwon YS, Kim EJ, Song H, Noh HK, Park SW

  • Infect Chemother.
  • 2020 Sep;52(3):352-359.
  • doi: 10.3947/ic.2020.52.3.352
Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is not differentiated clinically from other respiratory infections, and intensive care units (ICUs) are vulnerable to in-hospital transmission due to interventions inducing respiratory...
Overlooked and Challenging Encounters–Inflammatory Pseudotumors in the Abdomen and Pelvis: A Pictorial Essay

Kwag MH, Park JY, Jeong HW, Han JY, Lim JH, Kim YS, Park JW

  • J Korean Soc Radiol.
  • 2020 Sep;81(5):1121-1133.
  • doi: 10.3348/jksr.2019.0199
Inflammatory pseudotumors (IPTs) are uncommon, mass-forming lesions, predominantly involving the lung and orbit. Although the incidence of IPTs is rare in the abdomen and pelvis, they can be encountered as...
Advantages of ypTNM Staging in Post-surgical Prognosis for Initially Unresectable or Stage IV Gastric Cancers

Jeong GS, Lee IS, Park YS, Kim BS, Yoo MW, Yook JH, Kim BS

  • J Gastric Cancer.
  • 2020 Sep;20(3):233-244.
  • doi: 10.5230/jgc.2020.20.e20
Purpose: For unresectable or initially metastatic gastric cancer, conversion surgery (CVS), after systemic chemotherapy, has received attention as a treatment strategy. This study evaluated the prognostic value of ypTNM stage...
An Optimization of AAV-82Q-Delivered Rat Model of Huntington’s Disease

So KH, Choi JH, Islam J, KC E, Moon HC, Won SY, Kim HK, Kim S, Hyun SH, Park YS

  • J Korean Neurosurg Soc.
  • 2020 Sep;63(5):579-589.
  • doi: 10.3340/jkns.2019.0182
Objective : No optimum genetic rat Huntington model both neuropathological using an adeno-associated virus (AAV-2) vector vector has been reported to date. We investigated whether direct infection of an AAV2...
Association between body temperature measured at the emergency department with prognosis in septic shock patients

Choi JH, Park YS, Chung SP, Shin TG, Kim WY, Choi SH, Jo YH, Kang GH, Shin J, Lim TH, Han KS, Suh GJ, Korean Shock Society (KoSS) Investigators

  • J Korean Soc Emerg Med.
  • 2020 Aug;31(4):346-354.
Objective: Prior studies have explored the relationship between initial body temperature (BT) and mortality in patients with sepsis in the emergency department (ED). However, there has been no study on...
Gold Thread Implantation for Female Sexual Dysfunction and Vaginal Laxity: A Preliminary Investigation

Kim SM, Won YS, Kim SK

  • J Menopausal Med.
  • 2020 Aug;26(2):130-134.
  • doi: 10.6118/jmm.19024
Objectives: We evaluated the efficacy of gold thread implantation (GTI) in the vulva and vagina to improve female sexual dysfunction (FSD) and vaginal laxity. Methods: A retrospective chart review was conducted...
Agomelatine for the Treatment of Generalized Anxiety Disorder: A Meta-Analysis

Wang SM, Woo YS, Kim NY, Na HR, Lim HK, Bahk WM

  • Clin Psychopharmacol Neurosci.
  • 2020 Aug;18(3):423-433.
  • doi: 10.9758/cpn.2020.18.3.423
Objective: Despite multiple drugs available, a large proportion of patients with generalized anxiety disorder (GAD) do not show adequate response and remission. Thus, additional novel pharmacological agents are needed to...
Sedation for Brain Magnetic Resonance Imaging in Preterm Infants: Using Propofol under Anesthesiologist Supervision

Han YS, Kim HH, Kim HS, Yang MS, Ahn SY, Sung SI, Chang YS, Park WS

  • Neonatal Med.
  • 2020 Aug;27(3):105-110.
  • doi: 10.5385/nm.2020.27.3.105
Purpose: We aimed to compare two different sedation protocols for brain magnetic resonance imaging (MRI) in preterm infants. One protocol used chloral hydrate (CH) with monitoring conducted by non-anesthesiologists, and...
Comparison of Respiratory Outcomes between Less Invasive Surfactant Administration and the IntubationSurfactant-Extubation Technique in Premature Infants with Respiratory Distress Syndrome

Kim HS, Kim HH, Yang M, Han YS, Sung SI, Ahn SY, Chang YS, Park WS

  • Neonatal Med.
  • 2020 Aug;27(3):99-104.
  • doi: 10.5385/nm.2020.27.3.99
Purpose: To compare respiratory outcomes between less invasive surfactant admi nistration (LISA) and the intubation-surfactant-extubation (INSURE) technique in premature infants with respiratory distress syndrome (RDS). Methods: We performed a retrospective medical...
Influence of the Enhanced Recovery After Surgery Protocol on Postoperative Inflammation and Short-term Postoperative Surgical Outcomes After Colorectal Cancer Surgery

Jallounv HE, Lee IK, Kim MK, Sung NY, Turkistani SAA, Park SM, Won DY, Hong SH, Kye BH, Lee YS, Jeon HM

  • Ann Coloproctol.
  • 2020 Aug;36(4):264-272.
  • doi: 10.3393/ac.2020.03.25
Purpose: Many studies have shown that the enhanced recovery after surgery (ERAS) protocols improve postoperative surgical outcomes. The purpose of this study was to observe the effects on postoperative inflammatory...
Lung Disease Diagnostic Model Through IgG Sensitization to Microbial Extracellular Vesicles

Yang J, Hong G, Kim YS, Seo H, Kim S, McDowell A, Lee WH, Kim YS, Oh YM, Cho YS, Choi YW, Kim YY, Jee YK, Kim YK

  • Allergy Asthma Immunol Res.
  • 2020 Jul;12(4):669-683.
  • doi: 10.4168/aair.2020.12.4.669
Purpose: Recently, there has been a rise in the interest to understand the composition of indoor dust due to its association with lung diseases such as asthma, chronic obstructive pulmonary...
Clinical Perspectives of Parkinson's Disease for Ophthalmologists, Otorhinolaryngologists, Cardiologists, Dentists, Gastroenterologists, Urologists, Physiatrists, and Psychiatrists

Choi JH, Kim JM, Yang HK, Lee HJ, Shin CM, Jeong SJ, Kim WS, Han JW, Yoon IY, Song YS, Bae YJ

  • J Korean Med Sci.
  • 2020 Jul;35(28):e230.
  • doi: 10.3346/jkms.2020.35.e230
Parkinson's disease (PD) is a multisystemic disorder characterized by various non-motor symptoms (NMS) in addition to motor dysfunction. NMS include sleep, ocular, olfactory, throat, cardiovascular, gastrointestinal, genitourinary, or musculoskeletal disorders....
Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Kang JI, Choi YK, Koh YS, Hyun JW, Kang JH, Lee KS, Lee CM, Yoo ES, Kang HK

  • Biomol Ther.
  • 2020 Jul;28(4):354-360.
  • doi: 10.4062/biomolther.2019.206
The hair cycle (anagen, catagen, and telogen) is regulated by the interaction between mesenchymal cells and epithelial cells in the hair follicles. The proliferation of dermal papilla cells (DPCs), mesenchymal-derived...
Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation

Park YS, Kim SH, Park JW, Kho Y, Seok PR, Shin JH, Choi YJ, Jun JH, Jung HC, Kim EK

  • Intest Res.
  • 2020 Jul;18(3):325-336.
  • doi: 10.5217/ir.2019.00093
Background/Aims: Stress is closely related to the deterioration of digestive disease. Melatonin has potent anti-inflammatory properties. The objective of this study was to determine the effect of water stress (WS)...
Clinical application of ultrasonography-guided percutaneous liver biopsy and its safety over 18 years

Chang Y, Kim JI, Lee B, Kim SG, Jung MJ, Kim YS, Jeong SW, Jang JY, Yoo JJ

  • Clin Mol Hepatol.
  • 2020 Jul;26(3):318-327.
  • doi: 10.3350/cmh.2019.0019n
Background/Aims: Liver biopsy (LB) remains the gold standard for the evaluation of liver disease. However, over the past two decades, many noninvasive tests have been developed and utilized in clinical...
Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

Choi JY, Choi S, Lee M, Park YS, Sung JS, Chang WJ, Kim JW, Choi YJ, Kim J, Kim DS, Lee SH, Seok J, Park KH, Kim SH, Kim YH

  • Cancer Res Treat.
  • 2020 Jul;52(3):764-778.
  • doi: 10.4143/crt.2020.044
Purpose The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the...

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