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The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Lee HY, Nam Y, Choi WS, Kim TW, Lee J, Sohn UD

Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatoryproperties. We report here that eupatilin has a protective effect onthe ethanol-induced injury in rats. Sprague–Dawley rats were divided into 6 groups:control,...
The Altered Signaling on EFS-Induced Colon Contractility in Diabetic Rats

Thein W, Po WW, Kim DM, Sohn UD

Diabetes mellitus affects the colonic motility developing gastrointestinal symptoms, such as constipation. The aim of the study was to examine the role of intracellular signaling pathways contributing to colonic dysmotility...
Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats

Kwon KW, Nam Y, Choi WS, Kim TW, Kim GM, Sohn UD

Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in...
The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat

Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD

Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder...
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats

Han JS, Min YS, Kim GH, Chae SH, Nam Y, Lee J, Lee SY, Sohn UD

Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors....
Endothelium Independent Effect of Pelargonidin on Vasoconstriction in Rat Aorta

Min YS, Yoon HJ, Je HD, Lee JH, Yoo SS, Shim HS, Lee HY, La HO, Sohn UD

In this study, we investigated the effects of pelargonidin, an anthocyanidin found in many fruits and vegetables, on endothelium-independent vascular contractility to determine the underlying mechanism of relaxation. Isometric contractions...
The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents

Shin CY, Kim HS, Cha KH, Won DH, Lee JY, Jang SW, Sohn UD

A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study...
Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus

Kim JH, Sohn UD, Kim HG, Kim HR

The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central...
Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition

Chung YH, Oh KW, Kim ST, Park ES, Je HD, Yoon HJ, Sohn UD, Jeong JH, La HO

The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male...
Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells

Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD

A comprehensive collection of proteins senses local changes in intracellular Ca²⁺ concentrations ([Ca²⁺](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of...
Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response

Hyung KE, Kim SJ, Jang YW, Lee DK, Hyun KH, Moon BS, Kim B, Ahn H, Park SY, Sohn UD, Park ES, Hwang KW

Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study,...
Survey on Pharmacist's Awareness of E-commerce for Non-prescription Medicine

Park YD, Bang JS, Min YS, Sohn UD

OBJECTIVE: Online pharmacies were introduced in some countries such as United States of America or Canada. They can provide benefits to consumer because they can buy and take conveniently drugs...
The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line

Kim HS, Kim SJ, Bae J, Wang Y, Park SY, Min YS, Je HD, Sohn UD

Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is...
Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility

Je HD, Sohn UD, La HO

Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of...
The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle

Min CH, Wang Y, Bae J, Han JH, Sohn UD

To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide,...
Survey of Correlations on the Drug Use Patterns between Children and Their Parents

Hwang MY, Bang JS, Sohn UD

BACKGROUND: It is thought that drug use of parents is related to that of young children. The status of drug among young children's parents and a correlation of with parents...
The Effect of Polyphenols Isolated from Cynanchi wilfordii Radix with Anti-inflammatory, Antioxidant, and Anti-bacterial Activity

Jeong S, Lee S, Choi WJ, Sohn UD, Kim W

Recently, Cynanchi wilfordii Radix has gained wide use in Asian countries as a functional food effective for relieving fatigue, osteoporosis, and constipation, particularly in menopausal disorders. However, its anti-inflammatory and...
Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid

Kim H, Ro J, Barua S, Hwang DS, Na SJ, Lee HS, Jeong JH, Woo S, Kim H, Hong B, Yun G, Kim JH, Yoon YH, Park MG, Kim J, Sohn UD, Lee J

We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin,...
Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats

Joo M, Kim HS, Kwon TH, Palikhe A, Zaw TS, Jeong JH, Sohn UD

It has been shown that the extracts including eupatilin and quercetin-3-beta-D-glucuronopyranoside had mucoprotective effects on the esophagus and stomach through their antioxidant activities. This study was designed to investigate the...
Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

Kim WS, Choi WJ, Lee S, Kim WJ, Lee DC, Sohn UD, Shin HS, Kim W

The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of...

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