- Compositional changes in fecal microbiota in a new Parkinson’s disease model: C57BL/6‑Tg(NSE‑haSyn) mice
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Kim J, Kwon K, Jin Y, Seol A, Song H, Roh Y, Kim T, Park E, Park G, Park J, Jung Y, Cho J, Hwang D
- KMID: 2554158
- Lab Anim Res.
- 2023 Dec;39(4):371-384.
- doi: 10.1186/s42826-023-00181-4
Background The gut–brain axis (GBA) in Parkinson’s disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegenerative disease. Therefore, this study examined the compositional changes... -
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- Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N‑Trp53tm1Hw1 with TALEN‑mediated Trp53 mutant gene
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Yun W, Kim J, Jin Y, Roh Y, Song H, Seol A, Kim T, Min K, Park E, Park G, Kang H, Choi Y, Hwang D
- KMID: 2554151
- Lab Anim Res.
- 2023 Dec;39(4):287-297.
- doi: 10.1186/s42826-023-00175-2
Background To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, cell cycle distribution, apoptotic cell numbers and apoptotic... -
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