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197 results

Food Protein-induced Enterocolitis Mimic king Necrotizing Enterocolitis in a Premature Infant: Case Report

Lee SY, Jo CK, Rha SH, Kim MJ

  • Perinatology.
  • 2020 Sep;31(3):151-155.
  • doi: 10.14734/PN.2020.31.3.151
Food protein-induced enterocolitis (FPIES) is not well documented in newborns. Although FPIES is rare in premature infants, it may occasionally be confused with necrotizing enterocolitis (NEC). This is particularly true...
Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells

Kim HJ, Gong MK, Yoon CY, Kang J, Yun M, Cho NH, Rha SY, Choi YD

  • Yonsei Med J.
  • 2020 Jul;61(7):587-596.
  • doi: 10.3349/ymj.2020.61.7.587
Purpose: The current study aimed to investigate the synergistic antitumor effect of combined treatment with 17-DMAG (HSP90 inhibitor) and NVP-BEZ235 (PI3K/mTOR dual inhibitor) on cisplatin-resistant human bladder cancer cells. Materials and...
Behaviors and Attitudes toward the Use of Complementary and Alternative Medicine among Korean Cancer Patients

Kwon JH, Lee SC, Lee MA, Kim YJ, Kang JH, Kim JY, Lee HJ, Bae WK, Kim MJ, Chie EK, Kim J, Kim YH, Chung HC, Rha SY

  • Cancer Res Treat.
  • 2019 Jul;51(3):851-860.
  • doi: 10.4143/crt.2019.137
PURPOSE: A cross-sectional survey was conducted to explore the current awareness and use of complementary and alternative medicine (CAM), as well as attitudes toward CAM, in patients with cancer and...
Significance of Metabolic Tumor Volume and Total Lesion Glycolysis Measured Using ¹⁸F-FDG PET/CT in Locally Advanced and Metastatic Gallbladder Carcinoma

Chun YJ, Jeung HC, Park HS, Park JS, Rha SY, Choi HJ, Lee JH, Jeon TJ

  • Yonsei Med J.
  • 2019 Jul;60(7):604-610.
  • doi: 10.3349/ymj.2019.60.7.604
PURPOSE: This study aimed to determine the prognostic value of new quantitative parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally...
Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial

Kim MH, Zhang X, Jung M, Jung I, Park HS, Beom SH, Kim HS, Rha SY, Kim H, Choi YY, Son T, Kim HI, Cheong JH, Hyung WJ, Noh SH, Chung HC

  • Cancer Res Treat.
  • 2019 Apr;51(2):819-831.
  • doi: 10.4143/crt.2018.331
PURPOSE: Identification of biomarkers to predict recurrence risk is essential to improve adjuvant treatment strategies in stage II/III gastric cancer patients. This study evaluated biomarkers for predicting survival after surgical...
Pathological Characteristics of Prostate Cancer in Men Aged < 50 Years Treated with Radical Prostatectomy: a Multi-Centre Study in Korea

Chung MS, Shim M, Cho JS, Bang W, Kim SI, Cho SY, Rha KH, Hong SJ, Koo KC, Lee KS, Chung BH, Lee SH

  • J Korean Med Sci.
  • 2019 Mar;34(10):e78.
  • doi: 10.3346/jkms.2019.34.e78
BACKGROUND: Recently, younger prostate cancer (PCa) patients have been reported to harbour more favourable disease characteristics after radical prostatectomy (RP) than older men. We analysed young men (< 50 years)...
Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma

Lee JB, Park HS, Park S, Lee HJ, Kwon KA, Choi YJ, Kim YJ, Nam CM, Cho NH, Kang B, Chung HC, Rha SY

  • Cancer Res Treat.
  • 2019 Oct;51(4):1578-1588.
  • doi: 10.4143/crt.2018.671
PURPOSE: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment...
Characteristics and Treatment Patterns of Patients with Advanced Soft Tissue Sarcoma in Korea

Kim HS, Nam CM, Jang SY, Choi SK, Han M, Kim S, Moneta MV, Lee SY, Cho JM, Novick D, Rha SY

  • Cancer Res Treat.
  • 2019 Oct;51(4):1380-1391.
  • doi: 10.4143/crt.2018.476
PURPOSE: A soft tissue sarcoma (STS) is a rare type of cancer, accounting for 1% of adult solid cancers. The aim of the present study is to determine the incidence...
Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients

Lee SH, Lee B, Shim JH, Lee KW, Yun JW, Kim SY, Kim TY, Kim YH, Ko YH, Chung HC, Yu CS, Lee J, Rha SY, Kim TW, Jung KH, Im SA, Moon HG, Cho S, Kang JH, Kim J, Kim SK, Ryu HS, Ha SY, Kim JI, Chung YJ, Kim C, Kim HL, Park WY, Noh DY, Park K

  • Cancer Res Treat.
  • 2019 Jan;51(1):211-222.
  • doi: 10.4143/crt.2018.132
PURPOSE: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian...
S-1 Based Doublet as an Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer: Results from the Randomized Phase III POST Trial

Lee CK, Jung M, Kim HS, Jung I, Shin DB, Kang SY, Zang DY, Kim KH, Lee MH, Kim BS, Lee KH, Cheong JH, Hyung WJ, Noh SH, Chung HC, Rha SY

  • Cancer Res Treat.
  • 2019 Jan;51(1):1-11.
  • doi: 10.4143/crt.2018.028
PURPOSE: We conducted a randomized, multicenter, phase III trial to compare S-1 plus docetaxel (DS) with S-1 plus cisplatin (SP) as adjuvant chemotherapy for stage III gastric cancer patients. MATERIALS AND...
Transradial versus transfemoral intervention in ST-segment elevation myocardial infarction patients in Korean population

Li H, Rha SW, Choi BG, Shim MS, Choi SY, Choi CU, Kim EJ, Oh DJ, Cho BR, Kim MH, Kim DI, Jeong MH, Yoo SY, Jeong SS, Kim BO, Hyun MS, Youn YJ, Yoon J

  • Korean J Intern Med.
  • 2018 Jul;33(4):716-726.
  • doi: 10.3904/kjim.2016.316
BACKGROUND/AIMS: Transradial intervention (TRI) is becoming the preferred method over transfemoral intervention (TFI) because TRI is associated with lower incidence of major bleeding and vascular complications. However, there has been...
Five-Year Outcomes of Successful Percutaneous Coronary Intervention with Drug-Eluting Stents versus Medical Therapy for Chronic Total Occlusions

Rha SW, Choi BG, Baek MJ, Ryu YG, Li H, Choi SY, Byun JK, Mashaly A, Park Y, Jang WY, Kim W, Choi JY, Park EJ, Na JO, Choi CU, Lim HE, Kim EJ, Park CG, Seo HS, Oh DJ

  • Yonsei Med J.
  • 2018 Jul;59(5):602-610.
  • doi: 10.3349/ymj.2018.59.5.602
PURPOSE: Many recent studies have reported that successful percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) for chronic total occlusion (CTO) has more beneficial effects than failed CTO-PCI; however, there...
CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer

Kim SH, Park KH, Shin SJ, Lee KY, Kim TI, Kim NK, Rha SY, Ahn JB

  • Yonsei Med J.
  • 2018 Jul;59(5):588-594.
  • doi: 10.3349/ymj.2018.59.5.588
PURPOSE: Dysregulation of the Wnt pathway is a crucial step in the tumorigenesis of colorectal cancer (CRC). This study aimed to determine whether DNA methylation of Wnt pathway genes helps...
The Impact of Prediabetes on Two-Year Clinical Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention

Choi WG, Rha SW, Choi BG, Choi SY, Byun JK, Mashaly A, Park Y, Jang WY, Kim W, Choi JY, Park EJ, Na JO, Choi CU, Kim EJ, Park CG, Seo HS

  • Yonsei Med J.
  • 2018 Jun;59(4):489-494.
  • doi: 10.3349/ymj.2018.59.4.489
PURPOSE: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents...
Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study

Jung KS, Lee SJ, Park SH, Lee JL, Lee SH, Lim JY, Kang JH, Lee S, Rha SY, Lee KH, Kim HY, Lim HY

  • Cancer Res Treat.
  • 2018 Apr;50(2):488-494.
  • doi: 10.4143/crt.2016.584
PURPOSE: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy...
Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee

Kim MJ, Kim YS, Oh SY, Lee S, Choi YJ, Seol YM, Park MJ, Kim KH, Park LC, Kang JH, Hwang IG, Lee SI, Lim ST, Kim HS, Lim HY, Rha SY, Kim HJ

  • Korean J Intern Med.
  • 2018 Mar;33(2):383-390.
  • doi: 10.3904/kjim.2015.162
BACKGROUND/AIMS: Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma. METHODS: Eligible...
Low-Tube-Voltage CT Urography Using Low-Concentration-Iodine Contrast Media and Iterative Reconstruction: A Multi-Institutional Randomized Controlled Trial for Comparison with Conventional CT Urography

Kim SY, Cho JY, Lee J, Hwang SI, Moon MH, Lee EJ, Hong SS, Kim CK, Kim KA, Park SB, Sung DJ, Kim Y, Kim YM, Jung SI, Rha SE, Kim DW, Lee H, Shim Y, Hwang I, Woo S, Choi HJ

  • Korean J Radiol.
  • 2018 Dec;19(6):1119-1129.
  • doi: 10.3348/kjr.2018.19.6.1119
OBJECTIVE: To compare the image quality of low-tube-voltage and low-iodine-concentration-contrast-medium (LVLC) computed tomography urography (CTU) with iterative reconstruction (IR) with that of conventional CTU. MATERIALS AND METHODS: This prospective, multi-institutional, randomized...
Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions

Lee SH, Kim JE, Jang HS, Park KH, Oh BH, Shin SJ, Chung KY, Roh MR, Rha SY

  • Cancer Res Treat.
  • 2018 Oct;50(4):1378-1387.
  • doi: 10.4143/crt.2017.535
PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between...
Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin

Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY

  • Exp Mol Med.
  • 2018 Jan;50(1):e435.
  • doi: 10.1038/emm.2017.248
The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage. In...
Effectiveness and Safety of Biolimus A9â„¢-Eluting stEnt in Patients with AcUTe Coronary sYndrome; A Multicenter, Observational Study (BEAUTY Study)

Park KH, Jeong MH, Hong YJ, Ahn Y, Kim HK, Koh YY, Kim DI, Kim SW, Kim W, Rha SW, Rhew JY, Park JS, Park HS, Bae JH, Bae JW, Oh SK, Lee SY, Lee SW, Lee JH, Lim SY, Cho JH, Cha KS, Chae JK, Hur SH, Hwang SH, Hwang JY

  • Yonsei Med J.
  • 2018 Jan;59(1):72-79.
  • doi: 10.3349/ymj.2018.59.1.72
PURPOSE: This study sought to determine the 1-year clinical effectiveness and safety of a biodegradable, polymer-containing Biolimus A9â„¢-eluting stent (BES) in Korean patients with acute coronary syndrome (ACS). MATERIALS AND METHODS:...

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