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KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure

Lee JH, Seo HW, Ryu JY, Lim CJ, Yi KY, Oh KS, Lee BH

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of...
Diclofenac Inhibits Phorbol Ester-Induced Gene Expression and Production of MUC5AC Mucin via Affecting Degradation of IkBα and Translocation of NF-kB p65 in NCI-H292 Cells

Jin F, Li X, Lee HJ, Lee CJ

In this study, diclofenac, a non-steroidal anti-inflammatory drug, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. The human respiratory epithelial NCI-H292 cells...
Effect of core design on fracture resistance of zirconia-lithium disilicate anterior bilayered crowns

Ko KH, Park CJ, Cho LR, Huh YH

PURPOSE. The effect of core design on the fracture resistance of zirconia-lithium disilicate (LS2) bilayered crowns for anterior teeth is evaluated by comparing with that of metal-ceramic crowns. MATERIALS AND...
Recurrent pancreatitis in the setting of gallbladder agenesis,ansa pancreatica, Santorinicoele and eventual intraductal papillary mucinous neoplasia (IPMN)

Lee SW, Davidson CJ, Kia Y, Devereaux B, Godinho S, Appleyard M, O’Rourke N, Chandrasegaram MD

Gallbladder agenesis is a rare condition. Patients with gallbladder agenesis can present with biliary type symptoms and rarely pancreatitis. We present the case of a 35-year-old gentleman who was admitted...
Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs

Kim MU, Lee JH, Yoon CJ, Choi WS, Hur S, Chung JW

Purpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable nitinol stent (NiTi-stent) for peripheral arteries. Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned...
Lipoma on the Lower Lip

Ryu JY, Park CJ, Lee KH

  • KMID: 2504348
  • Korean J Dermatol.
  • 2020 Jul;58(6):416-418.
Lipoma is a very common benign tumor of the adipose tissue, but it occurs infrequently in the oral cavity. A 66-year-old man presented with an asymptomatic, solitary, 1×1-cm-sized yellowish mass...
Cognitive and Emotional Empathy in Young Adolescents: an fMRI Study

Kim EJ, Son JW, Park SK, Chung S, Ghim HR, Lee S, Lee SI, Shin CJ, Kim S, Ju G, Park H, Lee J

  • KMID: 2504042
  • J Korean Acad Child Adolesc Psychiatry.
  • 2020 Jul;31(3):121-130.
  • doi: 10.5765/jkacap.200020
Objectives: We investigated the differences in cognitive and emotional empathic ability between adolescents and adults, and the differences of the brain activation during cognitive and emotional empathy tasks. Methods: Adolescents (aged...
Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus

Li X, Jin F, Lee HJ, Lee CJ

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the...
Towards Understanding Tuberculosis- Related Issues in North Korea: A Narrative Review of North Korean Literature

Lee CJ, Lee S, Kim HJ, Kang YA

Background: North Korea is one of the 30 countries with the highest tuberculosis (TB) and drug-resistant TB burdened. To understand the medical issues and research trends associated with TB in...
Transplantation of a kidney from a donor with vancomycin-resistant Enterococci

Lim JH, Kim CJ, Oh JH, Cho AY, Chang MO, Kim YS, Lee KY, Sun IO

The colonization of vancomycin-resistant Enterococci before and after solid organ transplantation is associated with an increased risk of its infection. The prevalence of these bacterial colonies in renal transplant recipients...
Risk factors of postoperative remote intracerebral hemorrhage after craniotomy for ruptured cerebral aneurysms

Lee I, Park CW, You CJ, Choi DH, Park K, Kim YB, Kim WK, Yee GT, Kim MJ, Kim EY

Objective: We aimed to identify the relation between perioperative cerebrospinal fluid (CSF) drain through lumbar drainage (LD) and development of postoperative (POP) remote intracerebral hemorrhage (rICH) in craniotomy to treat...
Joint stability of internal conical connection abutments with or without hexagon indexes: an in vitro study

Lee SW, Cha MS, Lee JH, Cho LR, Park CJ

Purpose: The purpose of this study was to compare the axial displacement of the hexagonal and conical abutment in internal conical connection implant after screw tightening and cyclic loading. Materials...
The Relationship between Insomnia and Somatization According to Types of Work of Firefighters

Yoon H, Ju G, Lee SI, Shin CJ, Son JW, Kim S, Park H, Lee JH

Objectives:Firefighters are always under stress due to their job environment, and they are likely to become psychologically vulnerable due to continuous exposure to traumatic events, which is a stressful situation...
Endometrial profilin 1: a key player in embryo-endometrial crosstalk

Lee CJ, Hong SH, Yoon MJ, Lee KA, Ko JJ, Koo HS, Kim JH, Choi DH, Kwon H, Kang YJ

Objective: Despite extensive research on implantation failure, little is known about the molecular mechanisms underlying the crosstalk between the embryo and the maternal endometrium, which is critical for successful pregnancy....
Eupatilin treatment inhibits transforming growth factor beta-induced endometrial fibrosis in vitro

Lee CJ, Hong SH, Yoon MJ, Lee KA, Choi DH, Kwon H, Ko JJ, Koo HS, Kang YJ

Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic...
Multiorgan Serum IgG4-related Disease Diagnosed with Dermatopathology: A Case Report

Choi IH, Park CJ, Lee KH

  • KMID: 2502827
  • Korean J Dermatol.
  • 2020 May;58(4):273-275.
Immunoglobulin G4-related disease (IgG4-RD) is a recently discovered condition that was first reported in 2001. It is characterized by IgG4-positive plasma cell infiltration. Cutaneous involvement is rare but increasingly reported....
Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats

Kim JY, Yi ES, Lee H, Kim JS, Jee YS, Kim SE, Kim CJ, Ko IG

Purpose: Multiple sclerosis is an autoimmune disease that affects the central nerve system, resulting in cumulative loss of motor function. Multiple sclerosis is induced through multiple mechanisms and is caused...
Lipid-Lowering Efficacy and Safety of a New Generic Rosuvastatin in Koreans: an 8-Week Randomized Comparative Study with a Proprietary Rosuvastatin

Kim H, Lee CJ, Choi D, Kim BK, Kim IC, Kim JS, Ahn CM, Hong GR, Cho IJ, Shim CY, Lee SH

Objective: The aim of this study was to investigate whether a new generic rosuvastatin is non-inferior to a proprietary one in terms of lipid-lowering efficacy. We also evaluated its non-lipid...
Clinical, Laboratory, and Bone Marrow Findings of 31 Patients With Waldenström Macroglobulinemia

Ahn A, Park CJ, Cho YU, Jang S, Seo EJ, Lee JH, Yoon DH, Suh C

BACKGROUND: Waldenström macroglobulinemia (WM) is a subset of lymphoplasmacytic lymphoma (LPL) with bone marrow (BM) involvement and an IgM monoclonal gammopathy of any level. We aimed to identify the clinical,...
Sleep-enhancing Effects of Phytoncide Via Behavioral, Electrophysiological, and Molecular Modeling Approaches

Woo J, Lee CJ

  • KMID: 2500523
  • Exp Neurobiol.
  • 2020 Apr;29(2):120-129.
  • doi: 10.5607/en20013
Sleep is indispensable for living animals to live and maintain a normal life. Due to the growing number of people suffering from sleep disorders such as insomnia, there have been...

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