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Spatial Learning and Motor Deficits in Vacuolar Protein Sorting-associated Protein 13b (Vps13b) Mutant Mouse

Kim MJ, Lee RU, Oh J, Choi JE, Kim H, Lee K, Hwang SK, Lee JH, Lee JA, Kaang BK, Lim CS, Lee YS

  • Exp Neurobiol.
  • 2019 Aug;28(4):485-494.
  • doi: 10.5607/en.2019.28.4.485
Vacuolar protein sorting-associated protein 13B (VPS13B), also known as COH1, is one of the VPS13 family members which is involved in transmembrane transport, Golgi integrity, and neuritogenesis. Mutations in the...
Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors

Oh J, Lee C, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):237-249.
  • doi: 10.4196/kjpp.2019.23.4.237
Confirming the direct link between neural circuit activity and animal behavior has been a principal aim of neuroscience. The genetically encoded calcium indicator (GECI), which binds to calcium ions and...
Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner

Choi JE, Kim S, Lee J, Kim K, Kaang BK

  • Exp Neurobiol.
  • 2018 Oct;27(5):344-349.
  • doi: 10.5607/en.2018.27.5.344
Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms....
Inhibition of anterior cingulate cortex excitatory neuronal activity induces conditioned place preference in a mouse model of chronic inflammatory pain

Kang SJ, Kim S, Lee J, Kwak C, Lee K, Zhuo M, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2017 Sep;21(5):487-493.
  • doi: 10.4196/kjpp.2017.21.5.487
The anterior cingulate cortex (ACC) is known for its role in perception of nociceptive signals and the associated emotional responses. Recent optogenetic studies, involving modulation of neuronal activity in the...
Epigenetic regulation and chromatin remodeling in learning and memory

Kim S, Kaang BK

  • Exp Mol Med.
  • 2017 Jan;49(1):e281.
  • doi: 10.1038/emm.2016.140
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the...
Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice

Kim H, Son J, Yoo H, Kim H, Oh J, Han D, Hwang Y, Kaang BK

  • Exp Neurobiol.
  • 2016 Aug;25(4):156-162.
  • doi: 10.5607/en.2016.25.4.156
A primary characteristic of autism, which is a neurodevelopmental disorder, is impaired social interaction and communication. Furthermore, patients with autism frequently show abnormal social recognition. In mouse models of autism,...
Which Neurons Will Be the Engram - Activated Neurons and/or More Excitable Neurons?

Kim JI, Cho HY, Han JH, Kaang BK

  • Exp Neurobiol.
  • 2016 Apr;25(2):55-63.
  • doi: 10.5607/en.2016.25.2.55
During past decades, the formation and storage principle of memory have received much attention in the neuroscience field. Although some studies have attempted to demonstrate the nature of the engram,...
Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice

Lee J, Ko HG, Kim K, Kaang BK

  • Exp Neurobiol.
  • 2016 Dec;25(6):342-346.
  • doi: 10.5607/en.2016.25.6.342
Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in...
Metabotropic glutamate receptor dependent long-term depression in the cortex

Kang SJ, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):557-564.
  • doi: 10.4196/kjpp.2016.20.6.557
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The...
Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis

Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK

  • Exp Neurobiol.
  • 2015 Sep;24(3):246-251.
  • doi: 10.5607/en.2015.24.3.246
Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized...
CTCF as a multifunctional protein in genome regulation and gene expression

Kim S, Yu NK, Kaang BK

  • Exp Mol Med.
  • 2015 Jun;47(6):e166.
  • doi: 10.1038/emm.2015.33
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator...
Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse

Kwak C, Lim CS, Kaang BK

  • Exp Neurobiol.
  • 2015 Mar;24(1):84-89.
  • doi: 10.5607/en.2015.24.1.84
Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is...
Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity

Kim S, Kim T, Lee HR, Kong YY, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):515-522.
  • doi: 10.4196/kjpp.2015.19.6.515
Notch signaling is a key regulator of neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-2 (Mib2) is an essential positive...
Effect of Food Deprivation on a Delayed Nonmatch-to-place T-maze Task

Jang EH, Ahn SH, Lee YS, Lee HR, Kaang BK

  • Exp Neurobiol.
  • 2013 Jun;22(2):124-127.
  • doi: 10.5607/en.2013.22.2.124
Food deprivation can affect performance on difficult cognitive task, such as the delayed nonmatch-to-place T-maze task (DNMT). The importance of food deprivation on maintaining high motivation for DNMT task has...
Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory

Kwak C, Choi JH, Bakes JT, Lee K, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):293-296.
  • doi: 10.4196/kjpp.2012.16.5.293
Memory reconsolidation is ubiquitous across species and various memory tasks. It is a dynamic process in which memory is modified and/or updated. In experimental conditions, memory reconsolidation is usually characterized...
A Computational Model of the Temperature-dependent Changes in Firing Patterns in Aplysia Neurons

Hyun NG, Hyun KH, Hyun KB, Han JH, Lee K, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):371-382.
  • doi: 10.4196/kjpp.2011.15.6.371
We performed experiments using Aplysia neurons to identify the mechanism underlying the changes in the firing patterns in response to temperature changes. When the temperature was gradually increased from 11degrees...
Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron

Chae YS, Lee SH, Cheang YH, Lee N, Rim YS, Jang DJ, Kaang BK

  • Exp Mol Med.
  • 2010 Jan;42(1):30-37.
  • doi: 10.3858/emm.2010.42.1.003
The cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) binds to CPE containing mRNAs on their 3' untranslated regions (3'UTRs). This RNA binding protein comes out many important tasks, especially in learning...
Determination of Behavior and the Stimuli-dependent Transition of the Probability of Behavioral Expression: A Study on the Fluctuation of Behavioral State as Represented by the Level of Body Movement Suppression

Lee N, Kaang BK

  • Exp Neurobiol.
  • 2009 Dec;18(2):76-87.
  • doi: 10.5607/en.2009.18.2.76
The behavior of most animals is extremely complex. Despite accumulating knowledge about the mechanisms of neurons and nervous systems, which regulate these complex behaviors, we have little understanding about how...
Effects of Auditory Environment on Freezing Behavior of Mice in a Novel Context

Lee N, Im J, Son J, Kaang BK

  • Exp Neurobiol.
  • 2009 Dec;18(2):67-75.
  • doi: 10.5607/en.2009.18.2.67
Freezing behavior is a widely used parameter that represents the level of fear. A number of studies on emotional learning have used this behavior for quantification of fear that results...
Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior

Kwak C, Lee SH, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2009 Oct;13(5):357-360.
  • doi: 10.4196/kjpp.2009.13.5.357
It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data...

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